{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:58:24Z","timestamp":1792504704014,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2020,8,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Despite huge progress in hormonal therapy and improved\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    fertilization methods, the success rates in infertility treatment are still limited. A recently discovered mechanism revealed the interplay between the plasma protein fetuin\u2010B and the cortical granule\u2010based proteinase ovastacin to be a novel key mechanism in the regulation of fertilization. Upon sperm\u2013egg fusion, cleavage of a distinct zona pellucida component by ovastacin destroys the sperm receptor, enhances zona robustness, and eventually provides a definitive block against polyspermy. An untimely onset of this zona hardening prior to fertilization would consequently result in infertility. Physiologically, this process is controlled by fetuin\u2010B, an endogenous ovastacin inhibitor. Here we aimed to discover small\u2010molecule inhibitors of ovastacin that could mimic the effect of fetuin\u2010B. These compounds could be useful lead structures for the development of specific ovastacin inhibitors that can be used in infertility treatment or\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    fertilization\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202000397","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T07:30:14Z","timestamp":1592379014000},"page":"1499-1504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Primary Evaluation of Potential Small\u2010Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Treatment"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2802-2669","authenticated-orcid":false,"given":"Hagen","family":"K\u00f6rschgen","sequence":"first","affiliation":[{"name":"Institute of Molecular Physiology Cell and Matrix Biology 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