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Therefore, actin presents a potential target for malarial drug discovery, and naturally occurring actin inhibitors such as latrunculins are a promising starting point. However, the limited availability of the natural product and the laborious route for synthesis of latrunculins have hindered their potential development as drug candidates. In this regard, we recently described novel truncated latrunculins, with superior actin binding potency and selectivity towards <jats:italic>P. falciparum<\/jats:italic> actin than the canonical latrunculin B. In this paper, we further explore the truncated latrunculin core to summarize the SAR for inhibition of malaria motility. This study helps further understand the binding pattern of these analogues in order to develop them as drug candidates for malaria.<\/jats:p>","DOI":"10.1002\/cmdc.202000399","type":"journal-article","created":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T02:54:04Z","timestamp":1601175244000},"page":"679-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Structure\u2010Activity Studies of Truncated Latrunculin Analogues with Antimalarial Activity"],"prefix":"10.1002","volume":"16","author":[{"given":"Swapna","family":"Varghese","sequence":"first","affiliation":[{"name":"La Trobe Institute for Molecular Science La Trobe University  Melbourne Victoria 3086 Australia"},{"name":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences Monash University  Parkville Victoria 3052 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rapha\u00ebl","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences Monash University  Parkville Victoria 3052 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien R.","family":"Drew","sequence":"additional","affiliation":[{"name":"Burnet Institute 85 Commercial Road  Melbourne Victoria 3004 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G.","family":"Beeson","sequence":"additional","affiliation":[{"name":"Burnet Institute 85 Commercial Road  Melbourne Victoria 3004 Australia"},{"name":"Central Clinical School and Department of Microbiology Monash University  Melbourne Victoria 3004 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jake","family":"Baum","sequence":"additional","affiliation":[{"name":"Walter and Eliza Hall Institute  1G Royal Parade Parkville Victoria 3052 Australia"},{"name":"Department of Life Sciences Imperial College London  South Kensington SW7 2AZ UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J.","family":"Smith","sequence":"additional","affiliation":[{"name":"La Trobe Institute for Molecular Science La Trobe University  Melbourne Victoria 3086 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2114-8242","authenticated-orcid":false,"given":"Jonathan B.","family":"Baell","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences Monash University  Parkville Victoria 3052 Australia"},{"name":"Australian Translational Medicinal Chemistry Facility (ATMCF) Monash University  Parkville, Victoria 3052 Australia"},{"name":"ARC Centre for Fragment-Based Design Monash University  Parkville Victoria 3052 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"Malaria fact sheet.World Health Organizationaccess date 1 June 2019 https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/malaria."},{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","unstructured":"B. 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