{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:53:36Z","timestamp":1789674816877,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI106733"],"award-info":[{"award-number":["AI106733"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI136904"],"award-info":[{"award-number":["AI136904"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2020,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Drug\u2010resistant bacteria are rapidly becoming a significant problem across the globe. One element that factors into this crisis is the role played by bacterial biofilms in the recalcitrance of some infections to the effects of conventional antibiotics. Bacteria within a biofilm are highly tolerant of both antibiotic treatment and host immune responses. Biofilms are implicated in many chronic infections, including tuberculosis, in which they can act as bacterial reservoirs, requiring an arduous antibiotic regimen to eradicate the infection. A separate, compounding problem is that antibiotics once seen as last\u2010resort drugs, such as the polymyxin colistin, are now seeing more frequent usage as resistance to front\u2010line drugs in Gram\u2010negative bacteria becomes more prevalent. The increased use of such antibiotics inevitably leads to an increased frequency of resistance. Drugs that inhibit biofilms and\/or act as adjuvants to overcome resistance to existing antibiotics will potentially be an important component of future approaches to antibacterial treatment. We have previously demonstrated that analogues of the meridianin natural product family possess adjuvant and antibiofilm activities. In this study, we explore structural variation of the lead molecule from previous studies, and identify compounds showing both improved biofilm inhibition potency and synergy with colistin.<\/jats:p>","DOI":"10.1002\/cmdc.202000438","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T12:28:43Z","timestamp":1594729723000},"page":"1672-1679","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Second\u2010Generation Meridianin Analogues Inhibit the Formation of <i>Mycobacterium smegmatis<\/i> Biofilms and Sensitize Polymyxin\u2010Resistant Gram\u2010Negative Bacteria to Colistin"],"prefix":"10.1002","volume":"15","author":[{"given":"Michael J.","family":"Zeiler","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame, IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-4696","authenticated-orcid":false,"given":"Roberta J.","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame, IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame, IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.06.010306"},{"key":"e_1_2_7_2_1","unstructured":"Center for Disease Control and Prevention Antibiotic Resistance Threats In The United States 2019."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-015-1865-4"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2ob25835h"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12144"},{"key":"e_1_2_7_6_1","unstructured":"World Health Organization Global Tuberculosis Report 2019."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9MD00156E"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-38064-7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180925"},{"key":"e_1_2_7_10_1","first-page":"92","volume":"2020","author":"Brackett S. 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