{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:20:23Z","timestamp":1790709623132,"version":"4.1.0"},"reference-count":202,"publisher":"Wiley","issue":"24","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2020,12,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infections by flaviviruses, such as Dengue, West Nile, Yellow Fever and Zika viruses, represent a growing risk for global health. There are vaccines only for few flaviviruses while no effective treatments are available. Flaviviruses share epidemiological, structural, and ecologic features and often different viruses can co\u2010infect the same host. Therefore, the identification of broad\u2010spectrum inhibitors is highly desirable either for known flaviviruses or for viruses that likely will emerge in the future.<\/jats:p>\n                  <jats:p>Strategies targeting both virus and host factors have been pursued to identify broad\u2010spectrum antiflaviviral agents. In this review, we describe the most promising and best characterized targets and their relative broad\u2010spectrum inhibitors, identified by drug repurposing\/libraries screenings and by focused medicinal chemistry campaigns. Finally, we discuss about future strategies to identify new broad\u2010spectrum antiflavivirus agents.<\/jats:p>","DOI":"10.1002\/cmdc.202000464","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T20:51:40Z","timestamp":1600807900000},"page":"2391-2419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Broad\u2010Spectrum Flavivirus Inhibitors: a Medicinal Chemistry Point of View"],"prefix":"10.1002","volume":"15","author":[{"given":"Tommaso","family":"Felicetti","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Perugia  via del Liceo 1 06123 Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Manfroni","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Perugia  via del Liceo 1 06123 Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violetta","family":"Cecchetti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Perugia  via del Liceo 1 06123 Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolando","family":"Cannalire","sequence":"additional","affiliation":[{"name":"Department of Pharmacy University of Napoli \u201cFederico II\u201d  via D. 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