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One of the cationic Au<jats:sup>I<\/jats:sup> bis\u2010<jats:italic>N<\/jats:italic>\u2010heterocyclic carbenes (<jats:bold>3<\/jats:bold>) has low EC<jats:sub>50<\/jats:sub> values (ca. 4\u2005\u03bcM) in promastigotes cells and no toxicity in host macrophages. Together with two other Au<jats:sup>III<\/jats:sup> complexes (<jats:bold>6<\/jats:bold> and <jats:bold>7<\/jats:bold>), the compound is also extremely effective in intracellular amastigotes from <jats:italic>L.\u2005amazonensis<\/jats:italic>. Initial mechanistic studies include an evaluation of the gold complexes\u2032 effect on <jats:italic>L.\u2005amazonensis\u2019<\/jats:italic> plasma membrane integrity.<\/jats:p>","DOI":"10.1002\/cmdc.202000536","type":"journal-article","created":{"date-parts":[[2020,8,23]],"date-time":"2020-08-23T22:20:47Z","timestamp":1598221247000},"page":"2146-2150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Comparing the Antileishmanial Activity of Gold(I) and Gold(III) Compounds in <i>L. amazonensis<\/i> and <i>L. braziliensis in Vitro<\/i>"],"prefix":"10.1002","volume":"15","author":[{"given":"Karen","family":"Minori","sequence":"first","affiliation":[{"name":"Department of Animal Biology, Biology Institute University of Campinas (UNICAMP)  Rua Monteiro Lobato, 255 13083-862. 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