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Growing drug resistance against antibiotics demands alternative targets and mechanisms of action. As CA is essential for the survival of bacteria, such enzymes have the potential for developing new antibiotics. Most of the compounds presented excellent inhibition potential against VhCA \u03b3 compared to \u03b1 and \u03b2, with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values in the range of 82.5\u2013191.4\u2005nM. Several sulfonamides exhibited excellent inhibition against BpsCA \u03b2 with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values in the range of 394\u2013742.8\u2005nM. Recently it has been demonstrated that sufonamide CA inhibitors are effective against vancomycin\u2010resistant enterococci. These data show that CA inhibition of pathogenic bacteria may lead to a new class of antibiotics.<\/jats:p>","DOI":"10.1002\/cmdc.202000680","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T13:44:51Z","timestamp":1600868691000},"page":"2444-2447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Benzylaminoethylureido\u2010Tailed Benzenesulfonamides Show Potent Inhibitory Activity against Bacterial Carbonic Anhydrases"],"prefix":"10.1002","volume":"15","author":[{"given":"Majid","family":"Ali","sequence":"first","affiliation":[{"name":"NEUROFARBA Department University of Florence  Via Ugo Schiff 6 50019 Sesto Fiorentino Italy"},{"name":"Department of Chemistry COMSATS University Islamabad Abbottabad Campus  22060 Abbottabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department University of Florence  Via Ugo Schiff 6 50019 Sesto Fiorentino Italy"},{"name":"Centre of Advanced Research in Bionanoconjugates and Biopolymers - \u201cPetru Poni\u201d Institute of Macromolecular Chemistry  700487 Iasi Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Bozdag","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department University of Florence  Via Ugo Schiff 6 50019 Sesto Fiorentino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Carta","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department University of Florence  Via Ugo Schiff 6 50019 Sesto Fiorentino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemente","family":"Capasso","sequence":"additional","affiliation":[{"name":"Institute of Biosciences and Bioresources CNR  Via Pietro Castellino 111 80131 Napoli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umar","family":"Farooq","sequence":"additional","affiliation":[{"name":"Department of Chemistry COMSATS University Islamabad Abbottabad Campus  22060 Abbottabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department University of Florence  Via Ugo Schiff 6 50019 Sesto Fiorentino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"e_1_2_6_1_1","unstructured":"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/antibiotic resistance#:\u223c:text=Antibiotic%20resistance%20occurs%20when%20bacteria caused%20by%20non%2Dresistant%20bacteria. 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