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The distyryl BODIPYs containing two iodine atoms were designed to absorb in the red region, easily undergo intersystem crossing for efficient singlet oxygen generation, and additionally offer the possibility for coordination with mono\u2010activated transplatin. We were able to demonstrate that coordination of the BODIPYs with a mono\u2010activated transplatin increases the phototoxic index of the photosensitizers significantly, giving rise to highly phototoxic distyryl BODIPY derivatives, of which one was shown to have the highest ever reported phototoxic index against any cell line. Furthermore, the photophysical mechanism of singlet oxygen generation in distyryl BODIPYs undergoing intramolecular charge transfer was studied experimentally and using time\u2010dependent density functional theory.<\/jats:p>","DOI":"10.1002\/cmdc.202000702","type":"journal-article","created":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T22:13:59Z","timestamp":1604873639000},"page":"694-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Highly Phototoxic Transplatin\u2010Modified Distyryl\u2010BODIPY Photosensitizers for Photodynamic Therapy"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8463-2977","authenticated-orcid":false,"given":"Roxane","family":"Padrutt","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Zurich  Winterthurerstrasse 190 8057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0001-8783","authenticated-orcid":false,"given":"Vipin","family":"Babu","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Zurich  Winterthurerstrasse 190 8057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9951-1609","authenticated-orcid":false,"given":"Simon","family":"Klingler","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Zurich  Winterthurerstrasse 190 8057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9637-6122","authenticated-orcid":false,"given":"Martina","family":"Kalt","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Zurich  Winterthurerstrasse 190 8057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5594-3602","authenticated-orcid":false,"given":"Frank","family":"Schumer","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Zurich  Winterthurerstrasse 190 8057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4236-9036","authenticated-orcid":false,"given":"Maria I.","family":"Anania","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Zurich  Winterthurerstrasse 190 8057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-4560","authenticated-orcid":false,"given":"Lukas","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Zurich  Winterthurerstrasse 190 8057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3402-2016","authenticated-orcid":false,"given":"Bernhard","family":"Spingler","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Zurich  Winterthurerstrasse 190 8057 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20114"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1071"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/B915149B"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.07.058"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2009.04.001"},{"key":"e_1_2_7_6_1","first-page":"4085","volume":"17","author":"Tampa M.","year":"2019","journal-title":"Oncol. 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