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Moreover, the increasing number of multidrug\u2010resistant tuberculosis (MDR\u2010TB) cases has alarmed health agencies, warranting extensive efforts to discover novel drugs that are effective and also safe. In this study, 23 new compounds were synthesized and evaluated <jats:italic>in\u2005vitro<\/jats:italic> against the drug\u2010resistant strains of <jats:italic>M. tuberculosis<\/jats:italic>. The compound 6\u2010((3\u2010fluoro\u20104\u2010thiomorpholinophenyl)carbamoyl)benzo[<jats:italic>c<\/jats:italic>][1,2,5]oxadiazole 1\u2010<jats:italic>N<\/jats:italic>\u2010oxide (<jats:bold>5\u2009b<\/jats:bold>) was particularly remarkable in this regard as it demonstrated MIC<jats:sub>90<\/jats:sub> values below 0.28\u2005\u03bcM against all the MDR strains evaluated, thus suggesting that this compound might have a different mechanism of action. Benzofuroxans are an attractive new class of anti\u2010TB agents, exemplified by compound <jats:bold>5\u2009b<\/jats:bold>, with excellent potency against the replicating and drug\u2010resistant strains of <jats:italic>M. tuberculosis<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/cmdc.202000899","type":"journal-article","created":{"date-parts":[[2021,1,9]],"date-time":"2021-01-09T23:11:06Z","timestamp":1610233866000},"page":"1268-1282","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Benzofuroxan Derivatives as Potent Agents against Multidrug\u2010Resistant <i>Mycobacterium tuberculosis<\/i>"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7644-5466","authenticated-orcid":false,"given":"Guilherme F. 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