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The antiproliferative activity against a range of cancerous and normal cell lines has been determined, and show these complexes are particularly sensitive against the lung carcinoma cell line, A549. Annexin V (apoptosis) and Caspase\u20103\/7 assays were studied to confirm these complexes induce programmed cell death. While gel electrophoresis was used to determine DNA cleavage activity and production of reactive oxygen species (ROS), the Comet assay was used to determine induced genomic DNA damage. Additionally, F\u00f6rster resonance energy transfer (FRET)\u2010based DNA melting and fluorescent intercalation displacement assays have been used to determine the interaction of the complexes with double strand (DS) DNA and to establish preferential DNA base\u2010pair binding (AT versus GC).<\/jats:p>","DOI":"10.1002\/cmdc.202100152","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T03:14:55Z","timestamp":1618542895000},"page":"2402-2410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Understanding the Potential <i>In Vitro<\/i> Modes of Action of Bis(\u03b2\u2010diketonato) Oxovanadium(IV) Complexes"],"prefix":"10.1002","volume":"16","author":[{"given":"Baris","family":"Sergi","sequence":"first","affiliation":[{"name":"Gradute School of Health Sciences Ko\u00e7 University  34450 Sariyer Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ipek","family":"Bulut","sequence":"additional","affiliation":[{"name":"Gradute School of Health Sciences Ko\u00e7 University  34450 Sariyer Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xia","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of East Anglia Norwich Research Park  NR4 7TJ Norwich UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-0484","authenticated-orcid":false,"given":"Zo\u00eb A. 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