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Recently there has been an increased number of reports describing promising antimicrobial properties of metal\u2010containing compounds. Platinum complexes are well known in the field of inorganic medicinal chemistry for their tremendous success as anticancer agents. Here we report on the promising antibacterial properties of platinum cyclooctadiene (COD) complexes. Amongst the 15 compounds studied, the simplest compounds Pt(COD)X<jats:sub>2<\/jats:sub> (X=Cl, I, <jats:bold>Pt1<\/jats:bold> and <jats:bold>Pt2<\/jats:bold>) showed excellent activity against a panel of Gram\u2010positive bacteria including vancomycin and methicillin resistant <jats:italic>Staphylococcus aureus<\/jats:italic>. Additionally, the lead compounds show no toxicity against mammalian cells or haemolytic properties at the highest tested concentrations, indicating that the observed activity is specific against bacteria. Finally, these compounds showed no toxicity against <jats:italic>Galleria mellonella<\/jats:italic> at the highest measured concentrations. However, preliminary efficacy studies in the same animal model found no decrease in bacterial load upon treatment with <jats:bold>Pt1<\/jats:bold> and <jats:bold>Pt2<\/jats:bold>. Serum exchange studies suggest that these compounds exhibit high serum binding which reduces their bioavailability <jats:italic>in\u2005vivo<\/jats:italic>, mandating alternative administration routes such as e.\u2009g. topical application.<\/jats:p>","DOI":"10.1002\/cmdc.202100157","type":"journal-article","created":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T06:58:05Z","timestamp":1621580285000},"page":"3165-3171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Platinum Cyclooctadiene Complexes with Activity against Gram\u2010positive Bacteria"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6169-2491","authenticated-orcid":false,"given":"Angelo","family":"Frei","sequence":"first","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  St. Lucia QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Ramu","sequence":"additional","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  St. Lucia QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle J.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  St. Lucia QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hue","family":"Dinh","sequence":"additional","affiliation":[{"name":"ARC Centre of Excellence in Synthetic Biology Department of Molecular Sciences Macquarie University  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Semenec","sequence":"additional","affiliation":[{"name":"ARC Centre of Excellence in Synthetic Biology Department of Molecular Sciences Macquarie University  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alysha G.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  St. Lucia QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Zuegg","sequence":"additional","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  St. Lucia QLD 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Deckers","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Karlsruhe Institute of Technology (KIT)  Fritz-Haber-Weg 6 76131 Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Jung","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Karlsruhe Institute of Technology (KIT)  Fritz-Haber-Weg 6 76131 Karlsruhe Germany"},{"name":"Institute of Biological and Chemical Systems \u2013 Functional Molecular Systems (IBCS-FMS) Karlsruhe Institute of Technology (KIT)  Hermann-von-Helmholtz-Platz\u20051 76344 Eggenstein-Leopoldshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Br\u00e4se","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Karlsruhe Institute of Technology (KIT)  Fritz-Haber-Weg 6 76131 Karlsruhe Germany"},{"name":"Institute of Biological and Chemical Systems \u2013 Functional Molecular Systems (IBCS-FMS) Karlsruhe Institute of Technology (KIT)  Hermann-von-Helmholtz-Platz\u20051 76344 Eggenstein-Leopoldshafen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy K.","family":"Cain","sequence":"additional","affiliation":[{"name":"ARC Centre of Excellence in Synthetic Biology Department of Molecular Sciences Macquarie University  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A. 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