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Using a simple 2\u2010step synthetic route from dibromo\u2010 and dihydroxybenzenes, we obtained a structurally diverse broad panel of bis\u2010QACs with topologically distinct bridging connections between pyridinium heads. Selected analogs possessed potent broad\u2010spectrum biocidal activity against both bacterial and fungal pathogens: methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (ATCC 43300); <jats:italic>Escherichia coli<\/jats:italic> (ATCC 25922), <jats:italic>Klebsiella pneumonia<\/jats:italic> (ATCC 700603), <jats:italic>Acinetobacter baumannii<\/jats:italic> (ATCC 19606), <jats:italic>Pseudomonas aeruginosa<\/jats:italic> (ATCC 27853), <jats:italic>Candida albicans<\/jats:italic> (ATCC 90028), <jats:italic>Cryptococcus neoformans var. grubii<\/jats:italic> (ATCC 208821). Promising compounds displayed minimum inhibitory concentrations (MIC) values \u22640.25\u2005\u03bcg\/mL alongside improved cytotoxicity and hemolytic profiles compared to modern antiseptics. Thus, synthesized bis\u2010QACs represent a promising class of biocides with the potential to replace existing household sanitizers.<\/jats:p>","DOI":"10.1002\/cmdc.202100284","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T12:19:48Z","timestamp":1626092388000},"page":"2954-2959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Novel Phenyl\u2010Based Bis\u2010quaternary Ammonium Compounds as Broad\u2010Spectrum Biocides"],"prefix":"10.1002","volume":"16","author":[{"given":"Nikita A.","family":"Frolov","sequence":"first","affiliation":[{"name":"N. D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences  119991 Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ksenia A.","family":"Fedoseeva","sequence":"additional","affiliation":[{"name":"Mendeleev University of Chemical Technology of Russia  125047 Miusskaya square 9 Moscow Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl A.","family":"Hansford","sequence":"additional","affiliation":[{"name":"Centre for Superbug Solutions Institute for Molecular Bioscience The University of Queensland  Brisbane QLD 4072 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8675-4943","authenticated-orcid":false,"given":"Anatoly N.","family":"Vereshchagin","sequence":"additional","affiliation":[{"name":"N. D. 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