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Herein we describe the antimicrobial activity of cyclopentenones and derivatives that can be easily accessed from biomass derivatives furfural and 5\u2010hydroxymethylfurfural. Upon screening a range of functionalized <jats:italic>trans\u2010<\/jats:italic>diamino\u2010cyclopentenones (DCPs) and \u03b4\u2010lactone\u2010fused cyclopentenones (LCPs), an oxime ether derivative of DCP was identified that exhibited remarkable antimicrobial activity against Gram\u2010positive bacteria, including resistant strains such as methicillin\u2010resistant <jats:italic>S. aureus<\/jats:italic> (MRSA) and vancomycin\u2010resistant <jats:italic>E. faecalis<\/jats:italic> (VRE) strains.<\/jats:p>","DOI":"10.1002\/cmdc.202100369","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T15:09:51Z","timestamp":1623424191000},"page":"2781-2785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Functionalized Cyclopentenones and an Oxime Ether as Antimicrobial Agents"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2598-8540","authenticated-orcid":false,"given":"Rafael F. 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