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In this context, the \u201cmutual prodrug\u201d approach has emerged as a potential tool to overcome undesirable physicochemical features and mitigate the side effects of approved drugs. Among broad\u2010spectrum chemotherapeutics available for clinical use today, 5\u2010fluorouracil (5\u2010FU) is one of the most representative, also included in the World Health Organization model list of essential medicines. Unfortunately, severe side effects and drug resistance phenomena are still the primary limits and drawbacks in its clinical use. 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