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Most incidences occur in rural areas of resource\u2010limited countries, as such, timely and appropriate medical care for SBE is often inaccessible. The administration of anti\u2010snake venom serum (ASV) is the only effective definitive treatment of SBE, but treatment failure to available ASVs is not uncommon. Emerging evidence highlights the potential of small\u2010molecule compounds as inhibitors against toxins of snake venom. This presents an encouraging prospect to develop an alternative therapeutic option for the treatment SBE, that may be amenable for use at the point of care in resource\u2010constraint settings. In view of the pivotal role of natural products in modern drug discovery programmes, there is considerable interest in ethno\u2010pharmacological mining of medicinal plants and plant\u2010derived medicinal compounds toward developing novel snake venom\u2010neutralising therapeutics. In this review, we compile a collection of medicinal plants used in the treatment of SBE in West Africa and highlight their promise as potential botanical drugs or as sources of novel small\u2010molecule compounds for the treatment of SBE. The challenges that must be surmounted to bring this to fruition including the need for (sub) regional collaboration have been discussed.<\/jats:p>","DOI":"10.1002\/cmdc.202100478","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T22:14:42Z","timestamp":1632867282000},"page":"3635-3648","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prospects and Challenges of Developing Plant\u2010Derived Snake Antivenin Natural Products: A Focus on West Africa"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4557-859X","authenticated-orcid":false,"given":"Amina J.","family":"Yusuf","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical &amp; Medicinal Chemistry Usmanu Danfodiyo University  Sokoto Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0969-5526","authenticated-orcid":false,"given":"Godwin A.","family":"Aleku","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Cambridge  Cambridge CB2 1GA UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman Rabiu","family":"Bello","sequence":"additional","affiliation":[{"name":"Biotechnology unit Department of Life Sciences Mewar University  Gangrar Chittorgarh, Rajasthan India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dahiru Umar","family":"Liman","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical &amp; Medicinal Chemistry Usmanu Danfodiyo University  Sokoto Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40409-017-0127-6"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007059"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0050218"},{"key":"e_1_2_9_4_1","unstructured":"WHO Ed. 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