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This class of compounds was synthesized in good yields by a reaction of commercially available sulfanilamide and diorganyl diselenides in the presence of 10\u2005mol% of I\n                    <jats:sub>2<\/jats:sub>\n                    . Furthermore, the synthesized compound 4\u2010amino\u20103\u2010(phenylselenyl)benzenesulfonamide (\n                    <jats:bold>3\u2009a<\/jats:bold>\n                    ) was evaluated on complete Freund's adjuvant (CFA)\u2010induced acute inflammatory pain. Dose\u2010 and time\u2010response curves of antinociceptive effect of compound\n                    <jats:bold>3\u2009a<\/jats:bold>\n                    were performed using this experimental model. Also, the effect of compound\n                    <jats:bold>3\u2009a<\/jats:bold>\n                    was monitored in a hot\u2010plate test to evaluate the acute non\u2010inflammatory antinociception. The open\u2010field test was performed to evaluate the locomotor and exploratory behaviors of mice. Oxidative stress markers, such as glutathione peroxidase activity; reactive species, non\u2010protein thiols, and lipid peroxidation levels were performed to investigate the antioxidant action of compound\n                    <jats:bold>3\u2009a<\/jats:bold>\n                    . Our findings suggest that the antioxidant effect of compound\n                    <jats:bold>3\u2009a<\/jats:bold>\n                    may contribute to reducing the nociception and suppress the signaling pathways of inflammation on the local injury induced by CFA. Thus, compound\n                    <jats:bold>3\u2009a<\/jats:bold>\n                    reduced the paw edema as well as the hyperalgesic behavior in mice, being a promising therapeutic agent for the treatment of painful conditions.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202100507","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T21:58:38Z","timestamp":1638395918000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Synthesis and Evaluation of Antioxidant, Anti\u2010Edematogenic and Antinociceptive Properties of Selenium\u2010Sulfa Compounds"],"prefix":"10.1002","volume":"17","author":[{"given":"Manoela","family":"Sacramento","sequence":"first","affiliation":[{"name":"LASOL-CCQFA Universidade Federal de Pelotas \u2013 UFPel  P.O. 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