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Thus, the identification of innovative targets is an intriguing challenge in the drug and development process aimed at newer antimicrobial agents. The state\u2010of\u2010art of anticholera therapy might comprise the reduction of the expression of cholera toxin, which could be reached through the inhibition of carbonic anhydrases expressed in <jats:italic>Vibrio cholerae<\/jats:italic> (VchCA\u03b1, VchCA\u03b2, and VchCA\u03b3). Therefore, we focused our interest on the exploitation of sulfonamides as VchCA inhibitors. We planned to design and synthesize new benzenesulfonamides based on our knowledge of the VchCA catalytic site. The synthesized compounds were tested thus collecting useful SAR information. From our investigation, we identified new potent VchCA inhibitors, some of them displayed high affinity toward VchCA\u03b3 class, for which few inhibitors are currently reported in literature. The best interesting VchCA\u03b3 inhibitor (<jats:italic>S<\/jats:italic>)\u2010N\u2010(1\u2010oxo\u20101\u2010((4\u2010sulfamoylbenzyl)amino)propan\u20102\u2010yl)furan\u20102\u2010carboxamide (<jats:bold>40<\/jats:bold>) resulted more active and selective inhibitor when compared with acetazolamide (AAZ) as well as previously reported VchCA inhibitors.<\/jats:p>","DOI":"10.1002\/cmdc.202100510","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T14:34:06Z","timestamp":1633012446000},"page":"3787-3794","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["4\u2010Sulfamoylphenylalkylamides as Inhibitors of Carbonic Anhydrases Expressed in <i>Vibrio cholerae<\/i>"],"prefix":"10.1002","volume":"16","author":[{"given":"Francesca","family":"Mancuso","sequence":"first","affiliation":[{"name":"CHIBIOFARAM Department University of Messina  Viale Stagno D'Alcontres 98166 Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0614-5713","authenticated-orcid":false,"given":"Laura","family":"De Luca","sequence":"additional","affiliation":[{"name":"CHIBIOFARAM Department University of Messina  Viale Stagno D'Alcontres 98166 Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Bucolo","sequence":"additional","affiliation":[{"name":"CHIBIOFARAM Department University of Messina  Viale Stagno D'Alcontres 98166 Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milan","family":"Vrabel","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry and Biochemistry (IOCB) Czech Academy of Sciences  Flemingovo n\u00e1m. 2 16000 Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-7192","authenticated-orcid":false,"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department University of Florence  Via U. 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