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Except for Au, most metal\u2010based nanomaterials are unsuitable for clinical applications. The US Food and Drug Administration and other agencies have approved Feraheme and a few other iron oxide NPs for clinical use, paving the way for novel biocompatible immunoprotective superparamagnetic iron oxide nanohybrids to be developed as nanotherapeutics. A water\u2010soluble nanohybrid, referred to here as E\u2010NP, comprising superparamagnetic Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> NPs functionalised with tripyridyl porphyrin PS was introduced through a rigid 4\u2010carboxyphenyl linker. As a PDT agent, the efficacy of <jats:bold>E\u2010NP<\/jats:bold> toward the AGS cancer cell line showed enhanced photosensitising ability as determined through <jats:italic>in\u2005vitro<\/jats:italic> photobiological assays. The cellular uptake of <jats:bold>E\u2010NPs<\/jats:bold> by AGS cells led to apoptosis by upregulating ROS through cell\u2010cycle arrest and loss of mitochondrial membrane potential. The subcellular localisation of the PSs in mitochondria stimulated apoptosis through upregulation of p21, a proliferation inhibitor capable of preventing tumour development. Under both PDT and non\u2010PDT conditions, this nanohybrid can act as an anti\u2010inflammatory agent by decreasing the production of NO and superoxide ions in murine macrophages, thus minimising collateral damage to healthy cells.<\/jats:p>","DOI":"10.1002\/cmdc.202100550","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T16:08:56Z","timestamp":1635437336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["An Anti\u2010inflammatory Fe<sub>3<\/sub>O<sub>4<\/sub>\u2010Porphyrin Nanohybrid Capable of Apoptosis through Upregulation of p21 Kinase Inhibitor Having Immunoprotective Properties under Anticancer PDT Conditions"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-8664","authenticated-orcid":false,"given":"Devashish","family":"Sengupta","sequence":"first","affiliation":[{"name":"Department of Chemistry Assam University  Silchar Assam 788011 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9635-4967","authenticated-orcid":false,"given":"Subhojit","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Chemistry National Institute of Technology  Agartala Tripura 799046 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-8084","authenticated-orcid":false,"given":"Debdulal","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry Assam University  Silchar Assam 788011 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4926-7382","authenticated-orcid":false,"given":"Saran","family":"Chattopadhyaya","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Ramkrishna Mission Vivekananda Educational &amp; Research Institute Narendrapur  Kolkata 700103 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8696-4243","authenticated-orcid":false,"given":"Avinaba","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Zoology Charuchandra College  Kolkata West Bengal 700 029 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeaul Hoque","family":"Mazumdar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Assam University  Silchar Assam 788011 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7225-2926","authenticated-orcid":false,"given":"Biswajit","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Assam University  Silchar Assam 788 011 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1629-2979","authenticated-orcid":false,"given":"Samita","family":"Basu","sequence":"additional","affiliation":[{"name":"Chemical Sciences Division Saha Institute of Nuclear Physics  Kolkata West Bengal 700 064 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9488-0368","authenticated-orcid":false,"given":"Mahuya","family":"Sengupta","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Assam University  Silchar Assam 788 011 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.7.2.321"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1992.tb04222.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1071"},{"key":"e_1_2_7_4_1","first-page":"694","volume":"69","author":"Ohtani K.","year":"2016","journal-title":"Kyobu Geka (Jpn. 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