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In this work, we employed BSA\u2010CuS nanoparticles as a photothermal reagent to apply photothermal therapy (PTT) to combat drug\u2010resistant bacteria <jats:italic>in\u2005vitro<\/jats:italic> and subcutaneous abscess <jats:italic>in\u2005vivo<\/jats:italic>. The BSA\u2010CuS nanoparticles were found to be stable and biocompatible without cytotoxicity toward NIH3T3 and 4T1 cells. <jats:italic>In\u2005vitro<\/jats:italic> experiments showed that three species of drug\u2010resistant pathogens, including <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Staphylococcus aureus<\/jats:italic>, and <jats:italic>Candida albicans<\/jats:italic>, could be effectively sterilized under co\u2010incubation with BSA\u2010CuS nanoparticles and then irradiation with 1064\u2005nm NIR laser via tissue penetration. BSA\u2010CuS nanoparticles together with 1064\u2005nm NIR laser irradiation could also effectively diminish subcutaneous abscesses caused by drug\u2010resistant bacteria on mice under PTT and depth PTT without causing any serious side effects and organic damage <jats:italic>in\u2005vivo<\/jats:italic>.That is OK, thank you!<\/jats:p>","DOI":"10.1002\/cmdc.202100570","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T23:39:51Z","timestamp":1635723591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Transdermal Photothermal Sterilization and Abscess Elimination Research of BSA\u2010CuS Nanoparticles <i>in vivo<\/i>"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3255-2355","authenticated-orcid":false,"given":"Yan","family":"Zhao","sequence":"first","affiliation":[{"name":"The Second Hospital of Tianjin Medical University Department of Rheumatology and Immunology  Tianjin 300211 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing\u2010Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Hospital of Tianjin Medical University Department of Nephrology  Tianjin 300211 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010Xin","family":"Guo","sequence":"additional","affiliation":[{"name":"Chu Hsien-I Memorial Hospital of Tianjin Medical University Department of Endocrinology  Tianjin 300134 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang\u2010Qing","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Hospital of Tianjin Medical University Department of Clinical Laboratory  Tianjin 300211 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Hospital of Tianjin Medical University Institute of Urology  Tianjin 300211 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Tianjin Medical University Department of Ultrasound  Tianjin 300211 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Hospital of Tianjin Medical University Department of Nephrology  Tianjin 300211 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Qin","family":"Tang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Tianjin Medical University Institute of Urology  Tianjin 300211 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen\u2010Yu","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Hospital of Tianjin Medical University Department of Emergency  Tianjin 300211 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui\u2010Fen","family":"Yang","sequence":"additional","affiliation":[{"name":"The Second Hospital of Tianjin Medical University Department of Rheumatology and Immunology  Tianjin 300211 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Chen","sequence":"additional","affiliation":[{"name":"The Second Hospital of Tianjin Medical University Department of Emergency  Tianjin 300211 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"243","volume":"29","author":"Senneville E.","year":"2008","journal-title":"Rev. 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