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We report structure\u2010activity studies on sulfur analogues of ebselen with the Severe Acute Respiratory Syndrome coronavirus 2 (SARS\u2010CoV\u20102) main protease (M<jats:sup>pro<\/jats:sup>), employing turnover and protein\u2010observed mass spectrometry\u2010based assays. The results reveal scope for optimisation of ebselen\/ebselen derivative\u2010 mediated inhibition of M<jats:sup>pro<\/jats:sup>, particularly with respect to improved selectivity.<\/jats:p>","DOI":"10.1002\/cmdc.202100582","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T04:59:07Z","timestamp":1638334747000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Structure\u2010Activity Studies Reveal Scope for Optimisation of Ebselen\u2010Type Inhibition of SARS\u2010CoV\u20102 Main Protease"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3255-4716","authenticated-orcid":false,"given":"Siegfried T. 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