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In this context, we report the design and synthesis of 30 new non\u2010sulfonamide sulfocoumarin derivatives as CA inhibitors. They were investigated against hCA I and II (cytosolic isozymes) as well as hCA IX and XII (transmembrane, tumor\u2010associated enzymes). All compounds showed prominent selectivity for the tumor\u2010associated isoenzymes hCA IX and XII over the cytosolic isoenzymes hCA I and II. Among all synthesized compounds, 1\u2010(2,2\u2010dioxidobenzo[<jats:italic>e<\/jats:italic>][1,2]oxathiin\u20106\u2010yl)\u20103\u2010(o\u2010tolyl)urea(<jats:bold>5\u2009j<\/jats:bold>)and1\u2010(3\u2010fluorophenyl)\u20103\u2010(8\u2010methoxy\u20102,2\u2010dioxidobenzo[<jats:italic>e<\/jats:italic>][1,2]oxathiin\u20106\u2010yl)urea(<jats:bold>5\u2009q<\/jats:bold>)were found to be more potent and to have better inhibition constant values against hCA IX than the standard acetazolamide (AAZ), with <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub> values of 23.6 and 23.3\u2005nM, respectively. All other compounds were found to be active under <jats:italic>K<\/jats:italic><jats:sub>i<\/jats:sub>=920\u2005nM against hCA IX and XII.This study provides a new perspective for the future development of non\u2010sulfonamide derivatives as selective CA inhibitors.<\/jats:p>","DOI":"10.1002\/cmdc.202100725","type":"journal-article","created":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T22:36:26Z","timestamp":1639348586000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ureidosulfocoumarin Derivatives As Selective and Potent Carbonic Anhydrase IX and XII Inhibitors"],"prefix":"10.1002","volume":"17","author":[{"given":"Priti","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar, Hyderabad 500037 Telangana State India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilep","family":"Kumar Sigalapalli","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar, Hyderabad 500037 Telangana State India"},{"name":"Department of Pharmaceutical Chemistry Vignan Pharmacy College Jawaharlal Nehru Technological University  Vadlamudi 522213 Andhra Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nerella","family":"Sridhar Goud","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar, Hyderabad 500037 Telangana State India"},{"name":"Department of Neuroimaging and Interventional Radiology (NIIIR) National Institute of Mental Health and Neuro Sciences (NIMHANS)  Bengaluru 560027 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baijayantimala","family":"Swain","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar, Hyderabad 500037 Telangana State India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santosh","family":"Kumar Sahoo","sequence":"additional","affiliation":[{"name":"Department of Chemical Sciences National Institute of Pharmaceutical Education and Research (NIPER)  Balanagar, Hyderabad 500037 Telangana State India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi di Firenze Neurofarba Dept. 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