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Investigations of the structure\u2010activity relationship revealed the significance of the substituent at the <jats:italic>para<\/jats:italic>\u2010position of the aromatic ring. Also, the nature of the linker between a hydrophobic moiety and aromatic ring was clarified. Derivatives with <jats:italic>p<\/jats:italic>\u2010Cl, <jats:italic>p<\/jats:italic>\u2010Br, <jats:italic>p<\/jats:italic>\u2010CF<jats:sub>3,<\/jats:sub> and <jats:italic>p<\/jats:italic>\u2010NO<jats:sub>2<\/jats:sub> substituted aromatic ring and derivatives with cyclohexane ring showed the highest antiviral activity against vaccinia virus, cowpox, and ectromelia virus. The hydrazone and the amide group were more favourable as a linker for antiviral activity than the ester group. Compounds <jats:bold>3\u2009b<\/jats:bold> and <jats:bold>7\u2009e<\/jats:bold> with high antiviral activity were examined using the time\u2010of\u2010addition assay and molecular docking study. The results revealed the tested compounds to inhibit the late processes of the orthopoxvirus replication cycle and the p37 viral protein to be a possible biological target.<\/jats:p>","DOI":"10.1002\/cmdc.202100771","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T02:49:59Z","timestamp":1649299799000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Design, Synthesis, and Biological Evaluation of (+)\u2010Camphor\u2010 and (\u2212)\u2010Fenchone\u2010Based Derivatives as Potent Orthopoxvirus Inhibitors"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5227-9996","authenticated-orcid":false,"given":"Anastasiya S.","family":"Sokolova","sequence":"first","affiliation":[{"name":"Siberian Branch Russian Academy of Sciences N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry  pr. 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