{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:07:37Z","timestamp":1791828457510,"version":"4.3.4"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2022,6,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report aryl sulfonamide inhibitors of human carbonic anhydrase (hCA; EC 4.2.1.1) enzymes containing short ureido alkoxy tails. The inhibition potency of such compounds was investigated in vitro on the major hCA isoforms (i.e. I, II, IX, and XII). A selection of the most potent inhibitory derivatives against the hCA IX isoform (i.e. 5a, 5c, and 6c) was studied, and their binding modes on either hCA II and IX\u2010mimic isoform were assessed by X\u2010ray crystallography on the corresponding ligand\/protein adducts. This study adds to the field of developing hCA inhibitors at molecular level the critical interactions governing ligand selectivity.<\/jats:p>","DOI":"10.1002\/cmdc.202200148","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T05:19:18Z","timestamp":1649308758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Small Molecule Alkoxy Oriented Selectiveness on Human Carbonic Anhydrase II and IX Inhibition"],"prefix":"10.1002","volume":"17","author":[{"given":"Murat","family":"Bozdag","sequence":"first","affiliation":[{"name":"NEUROFARBA Department Sezione di Scienze Farmaceutiche e Nutraceutiche University of Florence  Via Ugo Schiff 6 Sesto Fiorentino 50019 Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lochlin","family":"Cravey","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology College of Medicine University of Florida  Gainesville FL 32610 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5657-4773","authenticated-orcid":false,"given":"Jacob","family":"Combs","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology College of Medicine University of Florida  Gainesville FL 32610 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anusha","family":"Kota","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology College of Medicine University of Florida  Gainesville FL 32610 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2792-935X","authenticated-orcid":false,"given":"Robert","family":"McKenna","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology College of Medicine University of Florida  Gainesville FL 32610 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department Sezione di Scienze Farmaceutiche e Nutraceutiche University of Florence  Via Ugo Schiff 6 Sesto Fiorentino 50019 Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Selleri","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department Sezione di Scienze Farmaceutiche e Nutraceutiche University of Florence  Via Ugo Schiff 6 Sesto Fiorentino 50019 Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Carta","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department Sezione di Scienze Farmaceutiche e Nutraceutiche University of Florence  Via Ugo Schiff 6 Sesto Fiorentino 50019 Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department Sezione di Scienze Farmaceutiche e Nutraceutiche University of Florence  Via Ugo Schiff 6 Sesto Fiorentino 50019 Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.86"},{"key":"e_1_2_8_2_1","first-page":"87re","volume":"87","author":"Matthew N.","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.5.540"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.9b00833"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2021.2004593"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c00383"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10212"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202103211"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ange.202103211"},{"key":"e_1_2_8_9_1","first-page":"4421","volume":"8","author":"Vincenzo A.","year":"2012","journal-title":"Chem. Rev."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.113035"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0cc02707c"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901287j"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053230X18018344"},{"key":"e_1_2_8_14_1","first-page":"2560","volume":"7","author":"Majid A.","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00636"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)62326-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.03.026"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/453543"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01906"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/742178"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.746972"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi802035f"},{"key":"e_1_2_8_23_1","first-page":"7210","volume":"22","author":"Pinard M. A.","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909047337"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910045749"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444909052925"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi902007b"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444910007493"},{"key":"e_1_2_8_29_1","volume-title":"The PyMOL molecular graphics system","author":"DeLano W. L.","year":"2002"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2007.05.022"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci200227u"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.202200148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cmdc.202200148","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.202200148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T13:02:36Z","timestamp":1760274156000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.202200148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,26]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,6,3]]}},"alternative-id":["10.1002\/cmdc.202200148"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.202200148","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,26]]},"assertion":[{"value":"2022-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202200148"}}