{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:31:27Z","timestamp":1791491487386,"version":"4.3.4"},"reference-count":62,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004054","name":"King Abdulaziz University","doi-asserted-by":"publisher","award":["RG-7-166-42"],"award-info":[{"award-number":["RG-7-166-42"]}],"id":[{"id":"10.13039\/501100004054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2022,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Three sets of isatin\u2010based Schiff bases were synthesized utilizing the molecular hybridization approach. Some of the synthesized Schiff bases show significant to moderate antiproliferative properties against MCF7 (breast), HCT116 (colon), and PaCa2 (pancreatic) cancer cell lines with potency compared to reference drugs 5\u2010fluorouracil (5\u2010FU) and Sunitinib. Among all, compound\n                    <jats:bold>17\u2009f<\/jats:bold>\n                    (3\u2010((1,5\u2010dimethyl\u20103\u2010oxo\u20102\u2010phenyl\u20102,3\u2010dihydro\u20101\n                    <jats:italic>H<\/jats:italic>\n                    \u2010pyrazol\u20104\u2010yl)imino)\u20101\u2010((1\u2010(2\u2010methoxyphenyl)\u20101\n                    <jats:italic>H<\/jats:italic>\n                    \u20101,2,3\u2010triazol\u20104\u2010yl)methyl)\u20105\u2010methylindolin\u20102\u2010one) exhibits promising antiproliferative properties against the MCF7 cancer cell line with 2.1\u2010fold more potency than Sunitinib. However, among all the synthesized compounds, three (5\u2010methylisatin derivatives) were the most effective against HCT116 in comparison to 5\u2010FU. Compound\n                    <jats:bold>17\u2009f<\/jats:bold>\n                    exhibited the highest anti\u2010angiogenic effect on the vasculature as it significantly reduced BV from 43\u2005mm to 2\u2005mm in comparison to 5.7\u2005mm for Sunitinib and flow cytometry supports the arrest of the cell cycle at G1\/S phases. In addition, compound\n                    <jats:bold>17\u2009f<\/jats:bold>\n                    also showed high VEGFR\u20102 inhibition properties against breast cancer cell lines. Robust 2D\u2010QSAR studies supported the biological data.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202200164","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T11:33:28Z","timestamp":1651750408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Development of Isatin\u2010Based Schiff Bases Targeting VEGFR\u20102 Inhibition: Synthesis, Characterization, Antiproliferative Properties, and QSAR Studies"],"prefix":"10.1002","volume":"17","author":[{"given":"Israa A.","family":"Seliem","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Organic Chemistry Faculty of Pharmacy Zagazig University  44519 Zagazig Egypt"},{"name":"Department of Chemistry and Physics Augusta University  30912 Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3668-104X","authenticated-orcid":false,"given":"Siva S.","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physics Augusta University  30912 Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4407-9745","authenticated-orcid":false,"given":"Adel S.","family":"Girgis","sequence":"additional","affiliation":[{"name":"Department of Pesticide Chemistry National Research Centre  Dokki 12622 Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Queen L.","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Physics Augusta University  30912 Augusta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona F.","family":"Said","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Cairo University  11562 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Bekheit","sequence":"additional","affiliation":[{"name":"Department of Pesticide Chemistry National Research Centre  Dokki 12622 Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar","family":"Abdelnaser","sequence":"additional","affiliation":[{"name":"Institute of Global Health and Human Ecology School of Sciences and Engineering The American University in Cairo (AUC)  11835 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soad","family":"Nasr","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology of Natural Products &amp; Clinical Pharmacology Ulm University  89081 Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walid","family":"Fayad","sequence":"additional","affiliation":[{"name":"Drug Bioassay-Cell Culture Laboratory Pharmacognosy Department National Research Centre  Dokki 12622 Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A. 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