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This causes an electrolyte imbalance and results in a spiral of negative effects on multiple organs, most notably the accumulation of thick mucus in the lungs, chronic respiratory tract infections and inflammation leading to pulmonary exacerbation and premature death. Progressive decline of lung function is mainly linked to persistent or recurring infections, mostly caused by bacteria, which require treatments with antibiotics and represent one of the major life\u2010limiting factors in subjects with CF. Treatment of such a complex disease require multiple drugs with a consequent therapeutic burden and complications caused by drug\u2010drug interactions and rapid emergence of bacterial drug resistance. We report herein our recent efforts in developing innovative multifunctional antibiotics specifically tailored to CF by a direct action on bacterial topoisomerases and a potential indirect effect on the pulmonary mucociliary clearance mediated by \u0394F508\u2010CFTR correction. The obtained results may pave the way for the development of a simplified therapeutic approach with a single agent acting as multifunctional Antibacterial\u2010Corrector.<\/jats:p>","DOI":"10.1002\/cmdc.202200277","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T03:34:45Z","timestamp":1653968085000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Towards Innovative Antibacterial Correctors for Cystic Fibrosis Targeting the Lung Microbiome with a Multifunctional Effect"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0168-2600","authenticated-orcid":false,"given":"Maria Grazia","family":"Martina","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze degli Alimenti e del Farmaco Universit\u00e0 degli Studi di Parma  Parco Area delle Scienze, 27\/A 43124 Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3001-8159","authenticated-orcid":false,"given":"Filomena","family":"Sannio","sequence":"additional","affiliation":[{"name":"Dipartimento di Biotecnologie Mediche Universit\u00e0 degli Studi di Siena  Viale Bracci 16 53100 Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuele","family":"Crespan","sequence":"additional","affiliation":[{"name":"Istituto di Genetica Molecolare IGM-CNR \u201cLuigi Luca Cavalli-Sforza\u201d  Via Abbiategrasso 207 27100 Pavi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marialaura","family":"Pavone","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze degli Alimenti e del Farmaco Universit\u00e0 degli Studi di Parma  Parco Area delle Scienze, 27\/A 43124 Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Simoncini","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze degli Alimenti e del Farmaco Universit\u00e0 degli Studi di Parma  Parco Area delle Scienze, 27\/A 43124 Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Barbieri","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze degli Alimenti e del Farmaco Universit\u00e0 degli Studi di Parma  Parco Area delle Scienze, 27\/A 43124 Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Perini","sequence":"additional","affiliation":[{"name":"Istituto di Genetica Molecolare IGM-CNR \u201cLuigi Luca Cavalli-Sforza\u201d  Via Abbiategrasso 207 27100 Pavi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Pesce","sequence":"additional","affiliation":[{"name":"U.O.C. 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