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One promising alternative to the development of new antibiotics is the use of antibiotic adjuvants, which would allow the continued use of FDA\u2010approved antibiotics that have been rendered ineffective due to resistance. Herein, we report a series of dipyrrins and pyrrole derivatives designed as analogues of prodigiosin and obatoclax, several of which potentiate the activity of colistin against <jats:italic>Klebsiella pneumoniae<\/jats:italic>, with lead compounds also potentiating colistin against <jats:italic>Acinetobacter baumannii<\/jats:italic> and <jats:italic>Pseudomonas aeruginosa<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/cmdc.202200286","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T15:32:55Z","timestamp":1655307175000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Simple Dipyrrin Analogues of Prodigiosin for Use as Colistin Adjuvants"],"prefix":"10.1002","volume":"17","author":[{"given":"Kittipan","family":"Siwawannapong","sequence":"first","affiliation":[{"name":"Department of Chemistry North Carolina State University  Raleigh NC 27695 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansley M.","family":"Nemeth","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8271-4696","authenticated-orcid":false,"given":"Roberta J.","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Chemistry North Carolina State University  Raleigh NC 27695 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of Chemistry North Carolina State University  Raleigh NC 27695 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Chemistry North Carolina State University  Raleigh NC 27695 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan E.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Lindsey","sequence":"additional","affiliation":[{"name":"Department of Chemistry North Carolina State University  Raleigh NC 27695 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Melander","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Notre Dame  Notre Dame IN 46556 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2021.e00604"},{"key":"e_1_2_8_2_1","author":"O\u2032Neil J.","year":"2014","journal-title":"Tackling a crisis for the health and wealth of nations. 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