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PMX substrates possess a conserved cleavage region denoted by the consensus motif, SF\n                    <jats:italic>h<\/jats:italic>\n                    E (\n                    <jats:italic>h<\/jats:italic>\n                    =hydrophobic amino acid). Peptidomimetics reflecting the P\n                    <jats:sub>3<\/jats:sub>\n                    \u2010P\n                    <jats:sub>1<\/jats:sub>\n                    positions of the consensus motif were designed and showed potent and selective inhibition of PMX. It was established that PMX prefers Phe in the P\n                    <jats:sub>1<\/jats:sub>\n                    position, di\u2010substitution at the \u03b2\u2010carbon of the P\n                    <jats:sub>2<\/jats:sub>\n                    moiety and a hydrophobic P\n                    <jats:sub>3<\/jats:sub>\n                    group which was supported by modelling of the peptidomimetics in complex with PMX. The peptidomimetics were shown to arrest asexual\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    parasites at the schizont stage by impairing PMX substrate processing. Overall, the peptidomimetics described will assist in further understanding PMX substrate specificity and have the potential to act as a template for future antimalarial design.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202200306","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:24:35Z","timestamp":1659140675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Substrate Peptidomimetic Inhibitors of\n                    <i>P. falciparum<\/i>\n                    Plasmepsin X with Potent Antimalarial Activity"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8877-1376","authenticated-orcid":false,"given":"Lachlan W.","family":"Richardson","sequence":"first","affiliation":[{"name":"Walter and Eliza Hall Institute of Medical Research  Parkville 3052 Victoria Australia"},{"name":"Department of Medical Biology University of Melbourne  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