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Aminoperoxides exhibit good cytotoxicity against lung A549 cancer cell line. Synthetic ozonides were shown to have high activity against the chloroquine\u2010resistant <jats:italic>P. falciparum<\/jats:italic>. A cyclic voltammetry study of peroxides was performed, and most of the compounds did not show a direct correlation in oxidative capacity\u2010activity. Peroxides were analyzed for ROS production to understand their mechanism of action. However, none of the compounds has an impact on ROS generation, suggesting that ozonides induce <jats:italic>apoptosis<\/jats:italic> in HepG2 cells through <jats:italic>ROS<\/jats:italic>\u2010<jats:italic>independent<\/jats:italic> dysfunction pathway.<\/jats:p>","DOI":"10.1002\/cmdc.202200328","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T02:04:50Z","timestamp":1661997890000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Antimalarial and Anticancer Activity Evaluation of Bridged Ozonides, Aminoperoxides, and Tetraoxanes"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0015-1453","authenticated-orcid":false,"given":"Paolo","family":"Coghi","sequence":"first","affiliation":[{"name":"School of Pharmacy Macau University of Science and Technology  Avenida Wai Long, Taipa Macau P. R. 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