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In this paper, we used a versatile method to construct mesoporous polydopamine nanovehicles (MPDA) with the dendritic mesopores loaded with a clinical chemotherapeutic drug, Doxorubicin (MPDA@DOX). The monodisperse nanoagents are spherical with a size of \u223c160\u2005nm and pore size of approximately 10\u2005nm. MPDA could efficiently delivery DOX with \u03c0\u2010\u03c0 stacking interaction and acts as the potent photothermal agents. Importantly, MPDA@DOX are preferentially internalized by cancerous cells, then bursting drug release and local hyperthermia generation were observed in conditions representative of the cytoplasm in tumor cells that highly synergistic cell killing effect were found under 808\u2005nm laser irradiation. The fluorescent imaging results of human breast tumor bearing murine model evidenced that MPDA delivery platform have excellent tumor precise targeting effect and <jats:italic>in\u2005vivo<\/jats:italic> tumor ablation experiment further revealed that MPDA@DOX showed markedly eradicated tumor growth capability under laser exposure. Therefore, this work provided a fascinating strategy based on biocompatible MPDA based drug delivery system for malignant tumors eradication via synergistic therapy.<\/jats:p>","DOI":"10.1002\/cmdc.202200360","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T08:06:08Z","timestamp":1661328368000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mesoporous Polydopamine\u2010Based Nanovehicles as a Versatile Drug Loading Platform to Enable Tumor\u2010Sufficient Synergistic Therapy"],"prefix":"10.1002","volume":"17","author":[{"given":"Suhua","family":"Jiang","sequence":"first","affiliation":[{"name":"Key Laboratory of Landscape Plants with Fujian and Taiwan Characteristics of Fujian Colleges and Universities Minnan Normal University  Zhangzhou 363000 P. R. 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