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For this study, to evaluate the antiviral activity of each enantiomer, we synthesized both enantiomers, as well as their corresponding bis(POM) prodrugs. Anti\u2010HIV\u20101 evaluation against the LAI strain and clinically NRTI\u2010resistant HIV\u20101 strains are presented. The activities against these different strains show that the activities of bis(POM) prodrug (\u2212)\u2010<jats:bold>9<\/jats:bold> are equivalent or even superior to those of (<jats:italic>R)\u2010<\/jats:italic>PMPA.<\/jats:p>","DOI":"10.1002\/cmdc.202200377","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T04:20:25Z","timestamp":1661746825000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Discovery of an L\u2010like Configuration for 3\u2019\u2010Fluoro\u20105\u2019\u2010norcarbonucleoside Phosphonates as Potent Anti\u2010HIV Agents"],"prefix":"10.1002","volume":"17","author":[{"given":"Pierre\u2010Yves","family":"Geant","sequence":"first","affiliation":[{"name":"Institut des Biomol\u00e9cules Max Mousseron (IBMM) UMR 5247 Universit\u00e9 de Montpellier, CNRS, ENSCM  1019, route de Mende 34293 Montpellier 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