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Despite intense research during the past three decades, progress towards small\u2010molecule inhibitors of mutant Ras proteins still has been limited. Only recently has significant progress been made, in particular with ligands for binding sites located in the switch II and between the switch\u2005I and switch\u2005II region of K\u2010Ras4B. However, the structural diversity of inhibitors identified for those sites to date is narrow. 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