{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:29:59Z","timestamp":1792542599726,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2022,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A series of pyrrolo[2,3\u2010\n                    <jats:italic>d<\/jats:italic>\n                    ]pyrimidines were designed\n                    <jats:italic>in silico<\/jats:italic>\n                    as potential bumped kinase inhibitors targeting\n                    <jats:italic>P. falciparum<\/jats:italic>\n                    calcium dependent protein kinase 4 (\n                    <jats:italic>Pf<\/jats:italic>\n                    CDPK4), with the potential to inhibit\n                    <jats:italic>Pf<\/jats:italic>\n                    CDPK1 based on earlier studies of the two kinases. A small series of these compounds were prepared and assessed for inhibitory activity against\n                    <jats:italic>Pf<\/jats:italic>\n                    CDPK4 and\n                    <jats:italic>Pf<\/jats:italic>\n                    CDPK1\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    . Four of the compounds displayed promising inhibitory activity against either\n                    <jats:italic>Pf<\/jats:italic>\n                    CDPK4 (IC\n                    <jats:sub>50<\/jats:sub>\n                    =0.210\u20130.530\u2005\u03bcM), or\n                    <jats:italic>Pf<\/jats:italic>\n                    CDPK1 (IC\n                    <jats:sub>50<\/jats:sub>\n                    =0.589\u2005\u03bcM). These data will enable optimisation of the molecular model to better predict inhibitory activity against\n                    <jats:italic>Pf<\/jats:italic>\n                    CDPK4.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202200421","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T08:04:15Z","timestamp":1663229055000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["7\n                    <i>H<\/i>\n                    \u2010Pyrrolo[2,3\u2010\n                    <i>d<\/i>\n                    ]pyrimidine\u20104\u2010amines as Potential Inhibitors of\n                    <i>Plasmodium falciparum<\/i>\n                    Calcium\u2010Dependent Protein Kinases"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8871-5251","authenticated-orcid":false,"given":"Tswene D.","family":"Seanego","sequence":"first","affiliation":[{"name":"Molecular Sciences Institute School of Chemistry University of the Witwatersrand  Private Bag 3 PO WITS 2050 South Africa"},{"name":"WITS Research Institute for Malaria (WRIM) University of the Witwatersrand  7 York Road Parktown 2193 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8361-2234","authenticated-orcid":false,"given":"Hlamulo E.","family":"Chavalala","sequence":"additional","affiliation":[{"name":"Molecular Sciences Institute School of Chemistry University of the Witwatersrand  Private Bag 3 PO WITS 2050 South Africa"},{"name":"WITS Research Institute for Malaria (WRIM) University of the Witwatersrand  7 York Road Parktown 2193 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-1484","authenticated-orcid":false,"given":"Hendrik H.","family":"Henning","sequence":"additional","affiliation":[{"name":"Molecular Sciences Institute School of Chemistry University of the Witwatersrand  Private Bag 3 PO WITS 2050 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B.","family":"de Koning","sequence":"additional","affiliation":[{"name":"Molecular Sciences Institute School of Chemistry University of the Witwatersrand  Private Bag 3 PO WITS 2050 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-1955","authenticated-orcid":false,"given":"Heinrich C.","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology Rhodes University  Makhanda 6140 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-2170","authenticated-orcid":false,"given":"Kayode K.","family":"Ojo","sequence":"additional","affiliation":[{"name":"Center for Emerging and Re-emerging Infectious Diseases (CERID) Division of Allergy and Infectious Diseases Department of Medicine University of Washington  Seattle WA 98109 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-1797","authenticated-orcid":false,"given":"Amanda L.","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Molecular Sciences Institute School of Chemistry University of the Witwatersrand  Private Bag 3 PO WITS 2050 South Africa"},{"name":"WITS Research Institute for Malaria (WRIM) University of the Witwatersrand  7 York Road Parktown 2193 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"\u00a0"},{"key":"e_1_2_8_2_2","unstructured":"WHO World Malaria Report2020;"},{"key":"e_1_2_8_3_2","unstructured":"WHO World Malaria Report2021."},{"key":"e_1_2_8_4_1","unstructured":"WHO 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