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CRE evade antibiotic treatments because these bacteria produce enzymes that degrade a wide range of antibiotics including carbapenems and \u03b2\u2010lactams. The formation of biofilms aggravates CRE infections, especially in a wound environment. These difficulties lead to persistent infection and non\u2010healing wounds. This creates the need for new compounds to overcome CRE antimicrobial resistance and disrupt biofilms. Recent studies in our lab show that 600\u2005Da branched polyethyleneimine (BPEI) and its derivative PEG350\u2010BPEI can overcome antimicrobial resistance and eradicate biofilms in methicillin\u2010resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    , methicillin\u2010resistant\n                    <jats:italic>S. epidermidis<\/jats:italic>\n                    ,\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    , and\n                    <jats:italic>E. coli<\/jats:italic>\n                    . In this study, the ability of 600\u2005Da BPEI and PEG350\u2010BPEI to eradicate carbapenem\u2010resistant\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    bacteria and their biofilms is demonstrated. We show that both BPEI and PEG350\u2010BPEI have anti\u2010biofilm efficacy against CRE strains expressing\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    carbapenemases (KPCs) and metallo\u2010\u03b2\u2010lactamases (MBLs), such as New Delhi MBL (NDM\u20101). Furthermore, our results illustrate that BPEI affects planktonic CRE bacteria by increasing bacterial length and width from the inability to proceed with normal cell division processes. These data demonstrate the multi\u2010functional properties of 600\u2005Da BPEI and PEG350\u2010BPEI to reduce biofilm formation and mitigate virulence in carbapenem\u2010resistant\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202200428","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T11:50:00Z","timestamp":1671623400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Eradicating Biofilms of Carbapenem\u2010Resistant\n                    <i>Enterobacteriaceae<\/i>\n                    by Simultaneously Dispersing the Biomass and Killing Planktonic Bacteria with PEGylated Branched Polyethyleneimine"],"prefix":"10.1002","volume":"18","author":[{"given":"Neda","family":"Heydarian","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center University of Oklahoma  101 Stephenson Parkway Norman OK 73019 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra L.","family":"Wouters","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center University of Oklahoma  101 Stephenson Parkway Norman OK 73019 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Neel","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center University of Oklahoma  101 Stephenson Parkway Norman OK 73019 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Ferrell","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center University of Oklahoma  101 Stephenson Parkway Norman OK 73019 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Panlilio","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center University of Oklahoma  101 Stephenson Parkway Norman OK 73019 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Haight","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center University of Oklahoma  101 Stephenson Parkway Norman OK 73019 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Biology University of Oklahoma  730 Van Vleet Oval, Room 314 Norman OK 73019 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1424-405X","authenticated-orcid":false,"given":"Charles V.","family":"Rice","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry Stephenson Life Sciences Research Center University of Oklahoma  101 Stephenson Parkway Norman OK 73019 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00080"},{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13756-018-0346-9","volume":"7","author":"Livorsi D. 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