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The intervention of NASH can prevent its further progression into hepatocarcinoma. In this study we have successfully constructed liver\u2010targeted Ce\u2010based hollow mesoporous nanocarriers loaded with bioactive drugs. This may provide an effective approach for eliminating NASH. Liver\u2010section\u2010specific targeting was realized by covalently linked galactose (Gal), which can be specifically recognized by receptors in the membranes of hepatocytes. Meanwhile, resveratrol (Res), a drug used to treat NASH, was efficiently loaded into the pores and cavity of CeO<jats:sub>2<\/jats:sub> (Res@H\u2212CeO<jats:sub>2<\/jats:sub>\u2212Gal). In steatotic HepG2 cells (free fatty acid induction), this nanosystem was found to enhance cellular Res internalization for improved anti\u2010lipogenesis activity. In mice with NASH, Res@H\u2212CeO<jats:sub>2<\/jats:sub>\u2212Gal increased Res delivery to liver sections for a reduction in lipid accumulation and enhanced anti\u2010inflammatory activity from the antioxidant capacity of Ce\u2010based nanocarriers. This effectively recovered NASH mice to the normal state. These findings show that the hepatic targeting and Res delivery nanoplatform could act as a safe and promising strategy for the elimination of NASH and other liver diseases.<\/jats:p>","DOI":"10.1002\/cmdc.202200468","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T23:24:59Z","timestamp":1668554699000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Hepatic\u2010Targeted Nano\u2010enzyme with Resveratrol Loading for Precise Relief of Nonalcoholic Steatohepatitis"],"prefix":"10.1002","volume":"18","author":[{"given":"Yili","family":"Tong","sequence":"first","affiliation":[{"name":"Department of General Practice Huadong Hospital Affiliated to Fudan University  No. 221 West Yan'an Road Shanghai 200040 P.R. 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