{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:53:32Z","timestamp":1789689212906,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Paracetamol and valproic acid are standalone drugs with leading position in the world drug market. The phosphonate analogues of these drugs were synthesized and were tested <jats:italic>in\u2005vivo. N<\/jats:italic>\u2010(4\u2010hydroxyphenylcarbamoyl)phosphonic acid was four times more potent than paracetamol in preventing acetic acid\u2010induced writhing. Phosphonate derivative of valproic acid, (2\u2010propylpentanoyl)phosphonic acid, had similar in\u2005vivo activity to valproic acid in the pentylenetetrazole\u2010induced kindling mouse model.<\/jats:p>","DOI":"10.1002\/cmdc.202200526","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T07:15:33Z","timestamp":1668150933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phosphonate Derivatives of Paracetamol and Valproic Acid"],"prefix":"10.1002","volume":"18","author":[{"given":"Ren\u00e1ta","family":"Ball\u00f3k","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry and Technology Budapest University of Technology and Economics  1521 Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Kis Varga","sequence":"additional","affiliation":[{"name":"Gedeon Richter Plc.  19\u201321 Gy\u00f6mr\u0151i \u00fat Budapest 1103 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6482-4450","authenticated-orcid":false,"given":"P\u00e9ter","family":"Erd\u00e9lyi","sequence":"additional","affiliation":[{"name":"Gedeon Richter Plc.  19\u201321 Gy\u00f6mr\u0151i \u00fat Budapest 1103 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Fischer","sequence":"additional","affiliation":[{"name":"Gedeon Richter Plc.  19\u201321 Gy\u00f6mr\u0151i \u00fat Budapest 1103 Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527630035.ch2"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2012.07.006"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.4.2.345"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/20014091111677"},{"key":"e_1_2_9_5_1","first-page":"61","volume":"22","author":"Nelson S. D.","year":"1978","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.07.054"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm800807k"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2006.02.004"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm900017f"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.695128"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2018-0591"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medidd.2020.100063"},{"key":"e_1_2_9_13_1","first-page":"875","volume":"49","author":"Frant J.","year":"2008","journal-title":"Tetrahedron Lett."},{"key":"e_1_2_9_14_1","first-page":"412","volume":"18","author":"Koster R.","year":"1959","journal-title":"Fed. Proc."},{"key":"e_1_2_9_15_1","first-page":"27","volume-title":"Antiepileptic Drugs. Mechanisms of Action","author":"Glaser H.","year":"1980"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(84)90159-0"},{"key":"e_1_2_9_17_1","first-page":"56573","volume":"136","author":"Shimada T.","year":"2018","journal-title":"J. Visualized Exp."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10426507.2014.974749"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(02)00140-3"},{"key":"e_1_2_9_20_1","unstructured":"D.\u2005C. Collins A.\u2005R. Gagliardi P. Nickel (University of Kentucky Research Foundation) US6096730 2000."},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm800824d"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2021.130321"},{"key":"e_1_2_9_23_1","unstructured":"A. Claesson B.\u2005M. Swahn (Astra AB) WO9208724 1992."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00312a021"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.202200526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cmdc.202200526","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.202200526","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T09:57:35Z","timestamp":1760263055000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.202200526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,2,14]]}},"alternative-id":["10.1002\/cmdc.202200526"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.202200526","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,24]]},"assertion":[{"value":"2022-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202200526"}}