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Various studies have shown that quinoline hydrazide\/hydrazone derivatives possess several biological activities, such as antimalarial, antitubercular, anticancer, anti\u2010inflammatory, and antimicrobial. Among these activities, the antibacterial activity of quinoline hydrazide\/hydrazone derivatives is noteworthy. The synthetic flexibility of the quinoline ring has led to the development of a wide range of structurally diverse quinoline hydrazide\/hydrazone derivatives, which can act at various bacterial targets such as DNA gyrase, glucosamine\u20106\u2010phosphate synthase, enoyl ACP reductase, and 3\u2010ketoacyl ACP reductase. This review emphasizes the antibacterial potential of various reported quinoline hydrazide\/hydrazone derivatives based on substitution in the quinoline ring. The antibacterial activity of various metal\u2010quinoline hydrazide\/hydrazone complexes is also discussed. 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