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Carboranes can be of importance in designing biologically active compounds due to their specific properties. Therefore, a series of novel acridine analogs modified with carborane clusters were synthesized. The DNA\u2010binding ability of these analogs was evaluated on calf thymus DNA (ct\u2010DNA). Results of these analyses showed that 9\u2010[(1,7\u2010dicarba\u2010<jats:italic>closo<\/jats:italic>\u2010dodecaborane\u20101\u2010yl)propylamino]acridine (<jats:bold>30<\/jats:bold>) interacted strongly with ct\u2010DNA, indicating its ability to intercalate into DNA, whereas 9\u2010[(1,7\u2010dicarba\u2010<jats:italic>closo<\/jats:italic>\u2010dodecaborane\u20101\u2010yl)propanamido]acridine (<jats:bold>29<\/jats:bold>) changed the B\u2010form of ct\u2010DNA to the Z form. Compound <jats:bold>30<\/jats:bold> demonstrated cytotoxicity, was able to inhibit cell proliferation, arrest the cell cycle in the S phase in the HeLa cancer cell line, and induced the production of reactive oxygen species (ROS). In addition, it was specifically localized in lysosomes and was a weak inhibitor of Topo II\u03b1.<\/jats:p>","DOI":"10.1002\/cmdc.202200666","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T04:50:02Z","timestamp":1675399802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Acridine\/Acridone\u2013Carborane Conjugates as Strong DNA\u2010Binding Agents with Anticancer Potential"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-8885","authenticated-orcid":false,"given":"Daria","family":"R\u00f3\u017cycka","sequence":"first","affiliation":[{"name":"Screening Laboratory Institute of Medical Biology Polish Academy of Sciences  106 Lodowa St. \u0141\u00f3d\u017a 93-232 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-7173","authenticated-orcid":false,"given":"Aleksandra","family":"Kowalczyk","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology Faculty of Biology and Environmental Protection University of Lodz  12\/16 Banacha St. \u0141\u00f3d\u017a 90-237 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4379-0367","authenticated-orcid":false,"given":"Marta","family":"Denel\u2010Bobrowska","sequence":"additional","affiliation":[{"name":"Screening Laboratory Institute of Medical Biology Polish Academy of Sciences  106 Lodowa St. \u0141\u00f3d\u017a 93-232 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1709-2971","authenticated-orcid":false,"given":"Olga","family":"Ku\u017amycz","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology Faculty of Biology and Environmental Protection University of Lodz  12\/16 Banacha St. \u0141\u00f3d\u017a 90-237 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3125-7920","authenticated-orcid":false,"given":"Magdalena","family":"Gapi\u0144ska","sequence":"additional","affiliation":[{"name":"Laboratory of Microscopic Imaging and Specialized Biological Techniques Faculty of Biology Environmental Protection University of Lodz  12\/16 Banacha St. \u0141\u00f3d\u017a 90-237 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4416-8289","authenticated-orcid":false,"given":"Pawe\u0142","family":"St\u0105czek","sequence":"additional","affiliation":[{"name":"Department of Molecular Microbiology Faculty of Biology and Environmental Protection University of Lodz  12\/16 Banacha St. \u0141\u00f3d\u017a 90-237 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4628-9017","authenticated-orcid":false,"given":"Agnieszka B.","family":"Olejniczak","sequence":"additional","affiliation":[{"name":"Screening Laboratory Institute of Medical Biology Polish Academy of Sciences  106 Lodowa St. \u0141\u00f3d\u017a 93-232 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,10]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2014.00055"},{"key":"e_1_2_8_2_1","unstructured":"\u00a0"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2014.902052"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.11.029"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA01026E"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026621666210804115203"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1984.34"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1986.tb04606.x"},{"key":"e_1_2_8_9_1","unstructured":"\u00a0"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00041a050"},{"key":"e_1_2_8_11_2","first-page":"989","volume":"68","author":"Kao-Shan C. 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