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Thymol has been used in medicine and agriculture for decades owing to its excellent therapeutic properties. However, in light of its poor aqueous solubility, thermal instability, and especially its high chemical volatility, the utility of thymol is hampered. The present work focuses on tuning the physicochemical properties of thymol by modifying its chemical structure through salt formation. In this context, a series of metal (Na, K, Li, Cu, and Zn) and ammonium (tetrabutylammonium and choline) salts of thymol were synthesized and characterized using IR, NMR, CHN elemental analysis, and DSC analyses. The molecular formulae of thymol salts were determined based on CHN analysis and thymol quantification studies from UV\u2010Vis spectrometric analysis. In most cases, the thymol phenolate was prepared as a 1\u2009:\u20091 molar ratio with metal\/ammonium ion. Only the Cu salt of thymol was isolated at a ratio of two phenolate units per copper ion. Most of the synthesized thymol salts were found to have increased thermal stability relative to thymol. The physicochemical properties such as solubility, thermal stability, and evaporation rate of thymol salts were thoroughly studied in comparison with thymol. The in\u2005vitro release studies of Cu from the copper salt of thymol is pH\u2010dependent: rapid release of copper was observed in the lower pH release medium (100\u2009% release at pH\u20051 for 12\u2005days) and the rates of release were slower at higher pH values (5\u2009% release at pH\u20052, and &lt;1\u2009% release at pH\u20054, 6, 8, and 10) over a period of about three weeks.<\/jats:p>","DOI":"10.1002\/cmdc.202300045","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T02:34:16Z","timestamp":1680489256000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Bioactive Phenolate Salts: Thymol Salts"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1779-8824","authenticated-orcid":false,"given":"Pulikanti Guruprasad","family":"Reddy","sequence":"first","affiliation":[{"name":"School of Pharmacy Faculty of Medicine The Institute of Drug Research and The Alex Grass Center for Drug Design and Synthesis The Hebrew University of Jerusalem  Jerusalem 91120 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2241-7726","authenticated-orcid":false,"given":"Abraham J.","family":"Domb","sequence":"additional","affiliation":[{"name":"School of Pharmacy Faculty of Medicine The Institute of Drug Research and The Alex Grass Center for Drug Design and Synthesis The Hebrew University of Jerusalem  Jerusalem 91120 Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"e_1_2_8_1_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010273"},{"key":"e_1_2_8_2_1","unstructured":"A.\u2005J. 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