{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:34:35Z","timestamp":1787319275106,"version":"build-2736575974"},"reference-count":74,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["YJKYYQ20210014"],"award-info":[{"award-number":["YJKYYQ20210014"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2023,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Drug\u2010resistant bacteria, such as methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    (MRSA), pose a serious threat to human life. Therefore, there is urgent need to develop antibiotics with new chemical structures and antibacterial mechanisms, especially those that elicit little drug resistance after long\u2010term use. Herein we synthesized three novel ruthenium complexes (Ru1\u2212Ru3) containing the enaminone structures for the first time. At a concentration of 5\u2005\u03bcM, Ru1\u2212Ru3 can lead to a CFU reduction of about 5 log units towards\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and MRSA. Interestingly, Ru3 displayed rapid bactericidal effects and could decrease the CFU numbers of both pathogens by 5 log units within 40\u2005min. The control compounds (Ru4 and Ru5) without the enaminone structures displayed very poor antibacterial activity under the same conditions. Moreover,\n                    <jats:italic>S. aureus<\/jats:italic>\n                    did not show apparent drug resistance towards Ru3 after 20 passages incubation with a sublethal concentration. These results highlight the critical role of enaminone structures for antibacterial applications.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202300065","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:37:12Z","timestamp":1675816632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ru(II) Complexes with Enaminone Structures for Rapid Sterilization of\n                    <i>Staphylococcus aureus<\/i>\n                    and MRSA with Little Accumulation of Drug Resistance"],"prefix":"10.1002","volume":"18","author":[{"given":"Yao","family":"Jian","sequence":"first","affiliation":[{"name":"Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing 100190 P.R. China"},{"name":"University of Chinese Academy of Sciences  Beijing 100049 P.R. 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