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Until today PZQ is the drug of choice for schistosomiasis in human medicine and used in many combinations with antinematode drugs in veterinary medicine. The Sm.TRPM\n                    <jats:sub>PZQ<\/jats:sub>\n                    , a Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010permeable transient receptor potential (TRP) channel, has been discovered as primary target of PZQ during the last decade. Furthermore, there is a short overview of routes of large\u2010scale synthesis of racemic and pure\n                    <jats:italic>(R)\u2010<\/jats:italic>\n                    PZQ. Until now racemic PZQ is used in veterinary and human medicine. In 2012 the Pediatric Praziquantel Consortium started PZQ chemistry and process development of pure\n                    <jats:italic>(R)\u2010<\/jats:italic>\n                    PZQ for human application. It is hoped that\n                    <jats:italic>(R)\u2010<\/jats:italic>\n                    PZQ will become available for pediatric use soon. The knowledge of the binding pocket of PZQ in Sm.TRPM\n                    <jats:sub>PZQ<\/jats:sub>\n                    allows to design synthesis of PZQ\u2010derivatives of the next generation for a target\u2010site directed screening. A similar screening should also be started for\n                    <jats:italic>Fasciola hepatica<\/jats:italic>\n                    TRPM\n                    <jats:sub>PZQ<\/jats:sub>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202300154","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T04:03:53Z","timestamp":1680494633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Praziquantel \u2013 50 Years of Research"],"prefix":"10.1002","volume":"18","author":[{"given":"Andreas","family":"Waechtler","sequence":"first","affiliation":[{"name":"Central Process Development Department (EL-OTS) Merck KGaA  Frankfurter Str. 250 64293 Darmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9633-7166","authenticated-orcid":false,"given":"Bertram","family":"Cezanne","sequence":"additional","affiliation":[{"name":"Central Process Development Department (EL-OTS) Merck KGaA  Frankfurter Str. 250 64293 Darmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8244-4515","authenticated-orcid":false,"given":"David","family":"Maillard","sequence":"additional","affiliation":[{"name":"Central Process Development Department (EL-OTS) Merck KGaA  Frankfurter Str. 250 64293 Darmstadt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Sun","sequence":"additional","affiliation":[{"name":"R&amp;D Department Valiant Pharmaceutical Co. 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Wuzhishan Road No. 11, YEDA, Yantai Shandong 264006 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achim","family":"Harder","sequence":"additional","affiliation":[{"name":"Department WE Biology Institute of Biology Heinrich-Heine University D\u00fcsseldorf  Universit\u00e4tsstra\u00dfe 1 40225 D\u00fcsseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"WHO: Weekly Epidemiological Record 50 11 December2020 629\u2013640."},{"key":"e_1_2_7_2_1","unstructured":"L.\u2005G. Goodwin inIllustrated History of Tropical Diseases (Ed.: F.\u2005E.\u2005G. 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