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We also tested a subset of these compounds against viruses with the amantadine\u2010resistant L26F, V27A, A30T, G34E M2 mutant channels. Four compounds inhibited WT M2 virus\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    with mid\u2010nanomolar potency, with 27 compounds showing sub\u2010micromolar to low micromolar potency. Several compounds inhibited L26F M2 virus\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    with sub\u2010micromolar to low micromolar potency, but only three compounds blocked L26F M2\u2010mediated proton current as determined by electrophysiology (EP). One compound was found to be a triple blocker of WT, L26F, V27A M2 channels by EP assays, but did not inhibit V27A M2 virus\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    , and one compound inhibited WT, L26F, V27A M2\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    without blocking V27A M2 channel. One compound blocked only L26F M2 channel by EP, but did not inhibit virus replication. The triple blocker compound is as long as rimantadine, but could bind and block V27A M2 channel due to its larger girth as revealed by molecular dynamics simulations, while MAS NMR informed on the interaction of the compound with M2(18\u201360) WT or L26F or V27A.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202300182","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T05:45:15Z","timestamp":1687931115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Study of the Activity of Adamantyl Amines against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple Blocker, Explored by Molecular Dynamics Simulations and Solid\u2010State NMR**"],"prefix":"10.1002","volume":"18","author":[{"given":"\u039carianna","family":"Stampolaki","sequence":"first","affiliation":[{"name":"Department of Pharmacy National and Kapodistrian University of Athens  Panepistimiopolis-Zografou 15771 Athens Greece"},{"name":"Department of NMR-Based Structural Biology Max Planck Institute for Biophysical Chemistry  Am Fassberg 11 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Jena University Hospital, CMB Building, R. 443  Hans Knoell Str. 2 07745 Jena (Germany) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Tekwani","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry University of Delaware  Newark DE 19716 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriakos","family":"Georgiou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National and Kapodistrian University of Athens  Panepistimiopolis-Zografou 15771 Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Tzitzoglaki","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National and Kapodistrian University of Athens  Panepistimiopolis-Zografou 15771 Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry The State University of New Jersey  160 Frelinghuysen Road Piscataway NJ 08854-8020 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of NMR-Based Structural Biology Max Planck Institute for Biophysical Chemistry  Am Fassberg 11 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Schmerer","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Jena University Hospital, CMB Building, R. 443  Hans Knoell Str. 2 07745 Jena (Germany) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"D\u00f6ring","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Jena University Hospital, CMB Building, R. 443  Hans Knoell Str. 2 07745 Jena (Germany) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Stylianakis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy National and Kapodistrian University of Athens  Panepistimiopolis-Zografou 15771 Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9732-2249","authenticated-orcid":false,"given":"Andreea L.","family":"Turcu","sequence":"additional","affiliation":[{"name":"Facultat de Farm\u00e0cia i Ci\u00e8ncies de l'Alimentaci\u00f3, and Institute of Biomedicine (IBUB) Universitat de Barcelona  Av. Joan XXIII, 27\u201331 Barcelona 08028 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry The State University of New Jersey  160 Frelinghuysen Road Piscataway NJ 08854-8020 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9296-6026","authenticated-orcid":false,"given":"Santiago","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Facultat de Farm\u00e0cia i Ci\u00e8ncies de l'Alimentaci\u00f3, and Institute of Biomedicine (IBUB) Universitat de Barcelona  Av. 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