{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T01:11:18Z","timestamp":1775610678386,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008569","name":"Oklahoma Center for the Advancement of Science and Technology","doi-asserted-by":"publisher","award":["HR18-013"],"award-info":[{"award-number":["HR18-013"]}],"id":[{"id":"10.13039\/100008569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007147","name":"University of Tulsa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2023,10,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In an effort to further investigate previously observed activity of indolyl sulfonamides towards pancreatic cancer cell lines, a library of 44\u2005compounds has been synthesized. The biological activity of the compounds has been determined using two different screening assay techniques against 7\u2005pancreatic cancer cell lines and 9\u2005non\u2010pancreatic cancer cell lines. In the first assay, the cytotoxicity of the compounds was evaluated using a traditional (48\u2005hour compound exposure) method. An <jats:italic>in silico<\/jats:italic> investigation was conducted to determine if the compounds might be inducing cell death by inhibiting the S100A2\u2010p53 protein\u2010protein interaction. In the second assay, the potential role of the compounds as metabolic inhibitors of ATP production was evaluated using a rapid screening (1\u20132\u2005hour compound exposure) method. IC<jats:sub>50<\/jats:sub> values of the hit compounds were obtained and four compounds displayed sub\u2010micromolar potency against PANC\u20101 cells. The investigation has provided several compounds that display selective <jats:italic>in\u2005vitro<\/jats:italic> activity toward pancreatic cancer that warrant further development.<\/jats:p>","DOI":"10.1002\/cmdc.202300265","type":"journal-article","created":{"date-parts":[[2023,7,8]],"date-time":"2023-07-08T05:49:39Z","timestamp":1688795379000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Expansion of a Synthesized Library of <i>N<\/i>\u2010Benzyl Sulfonamides Derived from an Indole Core to Target Pancreatic Cancer"],"prefix":"10.1002","volume":"18","author":[{"given":"Megan D.","family":"Hopkins","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Tulsa  800 South Tucker Drive 74104 Tulsa OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian J.","family":"Costello","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Tulsa  800 South Tucker Drive 74104 Tulsa OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary C.","family":"Brandeburg","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Tulsa  800 South Tucker Drive 74104 Tulsa OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily L.","family":"Slay","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Tulsa  800 South Tucker Drive 74104 Tulsa OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levi A.","family":"Zanders","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Tulsa  800 South Tucker Drive 74104 Tulsa OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline E.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Tulsa  800 South Tucker Drive 74104 Tulsa OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina A.","family":"Derewonko","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Tulsa  800 South Tucker Drive 74104 Tulsa OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin L.","family":"Davitt","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Tulsa  800 South Tucker Drive 74104 Tulsa OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madison A.","family":"Reeder","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Tulsa  800 South Tucker Drive 74104 Tulsa OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Prichard","sequence":"additional","affiliation":[{"name":"Chemistry, School of Environmental &amp; Life Sciences The University of Newcastle  University Drive 2308 Callaghan NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Chiew","sequence":"additional","affiliation":[{"name":"Chemistry, School of Environmental &amp; Life Sciences The University of Newcastle  University Drive 2308 Callaghan NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"McCluskey","sequence":"additional","affiliation":[{"name":"Chemistry, School of Environmental &amp; Life Sciences The University of Newcastle  University Drive 2308 Callaghan NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Sheaff","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Tulsa  800 South Tucker Drive 74104 Tulsa OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2962-0137","authenticated-orcid":false,"given":"Angus A.","family":"Lamar","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry The University of Tulsa  800 South Tucker Drive 74104 Tulsa OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"\u00a0"},{"key":"e_1_2_8_2_2","unstructured":"American Cancer Society Cancer Facts and Figures 2022.http:\/\/www.cancer.org\/content\/dam\/cancer-org\/research\/cancer-facts-and-statistics\/annual-cancer-facts-and-figures\/2022\/2022-cancer-facts-and-figures.pdf;"},{"key":"e_1_2_8_3_2","unstructured":"American Cancer Society Pancreatic Cancer overview.http:\/\/www.cancer.org\/cancer\/pancreatic-cancer.html."},{"key":"e_1_2_8_4_1","unstructured":"\u00a0"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i43.4846"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13026"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102016"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0281-6"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/C9MD00447E"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.12.035"},{"key":"e_1_2_8_11_1","unstructured":"\u00a0"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/C6OB00616G"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7OB02120H"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23081838"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1039\/D0OB02429E"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1039\/D2OB01291J"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9OB01694E"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c02203"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202000949"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.10.002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1633"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2008.03.019"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202000950"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2022.128591"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0714"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2250"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-014-2117-4"},{"key":"e_1_2_8_28_1","unstructured":"A.\u2005A. Lamar R.\u2005J. Sheaff Synthesis of N-benzyl sulfonamides useful for treatment of cancer. PCT Int. Appl. WO 2022020742\u2005A1 20220127 (2022)."},{"key":"e_1_2_8_29_1","unstructured":"\u00a0"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.021"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012383"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2015.05.007"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4145"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2016.60"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209597"},{"key":"e_1_2_8_36_1","unstructured":"\u00a0"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-3928"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.03.018"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2018.08.001"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.202300265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T16:26:03Z","timestamp":1760286363000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.202300265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,20]]},"references-count":39,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2023,10,4]]}},"alternative-id":["10.1002\/cmdc.202300265"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.202300265","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,20]]},"assertion":[{"value":"2023-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202300265"}}