{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:39:46Z","timestamp":1792618786128,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemMedChem"],"published-print":{"date-parts":[[2023,10,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The tumor\u2010expressed human carbonic anhydrase (hCA) isoforms hCA\u2005IX and hCA\u2005XII have been extensively studied to develop anticancer agents targeting solid tumors in combined therapy. These CA\u2005 isoforms are considered key factors in controlling tumor microenvironment (TME) of cancer lines that develop high metastatic activity. Herein, we report the discovery of potent hCA\u2005IX\/hCA\u2005XII inhibitors that were disclosed through a screening campaign on an in\u2010house collection of arylsulfonamides preliminary tested toward other hCAs. Among them, the\n                    <jats:italic>N<\/jats:italic>\n                    \u2010(4\u2010sulfamoylphenyl)naphthalene\u20102\u2010carboxamide (\n                    <jats:bold>12<\/jats:bold>\n                    ) and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010(4\u2010sulfamoylphenyl)\u20103,4\u2010dihydroisoquinoline\u20102(1\n                    <jats:italic>H<\/jats:italic>\n                    )\u2010carbothioamide (\n                    <jats:bold>15<\/jats:bold>\n                    ) proved to be the most intriguing hCA\u2005IX\/hCA\u2005XII inhibitors displaying favourable selectivity ratios over widespread hCA\u2005I and hCA\u2005II isoforms. To explore their binding mode, we conducted docking studies that described the poses of the best inhibitors in the catalytic site of hCA\u2005IX and hCA\u2005XII, thus suggesting the privileged pattern of interactions. These structural findings might further improve the knowledge for a successful identification of new sulfonamides as adjuvant agents in cancer management.\n                  <\/jats:p>","DOI":"10.1002\/cmdc.202300330","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T08:10:18Z","timestamp":1694419818000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Screening Campaign and Docking Investigations in Identifying New Hit Compounds as Inhibitors of Human Carbonic Anhydrases Expressed In Tumour Cells"],"prefix":"10.1002","volume":"18","author":[{"given":"Federico","family":"Ricci","sequence":"first","affiliation":[{"name":"CHIBIOFARAM Department University of Messina  Viale F. d'Alcontres 31 98166 Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department University of Florence  Via Ugo Schiff 6 50019 Sesto Fiorentino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mancuso","sequence":"additional","affiliation":[{"name":"CHIBIOFARAM Department University of Messina  Viale F. d'Alcontres 31 98166 Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"De Luca","sequence":"additional","affiliation":[{"name":"CHIBIOFARAM Department University of Messina  Viale F. d'Alcontres 31 98166 Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department University of Florence  Via Ugo Schiff 6 50019 Sesto Fiorentino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0002-2253","authenticated-orcid":false,"given":"Rosaria","family":"Gitto","sequence":"additional","affiliation":[{"name":"CHIBIOFARAM Department University of Messina  Viale F. d'Alcontres 31 98166 Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2021"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2020.1743679"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2020.1743676"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2019.1651289"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00062"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.20517\/cdr.2021.134"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14061392"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.105920"},{"key":"e_1_2_9_9_1","first-page":"343","volume":"4","author":"Tonissen K. F.","year":"2021","journal-title":"Cancer Drug Resist"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202200562"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00007"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28020890"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2022.2053526"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01390"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.202200383"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202100510"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm101541x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm9014026"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btaa774"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0897"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci049885e"}],"container-title":["ChemMedChem"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.202300330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cmdc.202300330","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cmdc.202300330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:11:17Z","timestamp":1792617077000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.202300330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,22]]},"references-count":21,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2023,10,17]]}},"alternative-id":["10.1002\/cmdc.202300330"],"URL":"https:\/\/doi.org\/10.1002\/cmdc.202300330","archive":["Portico"],"relation":{},"ISSN":["1860-7179","1860-7187"],"issn-type":[{"value":"1860-7179","type":"print"},{"value":"1860-7187","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,22]]},"assertion":[{"value":"2023-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202300330"}}