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The anticancer activities of all newly synthesized compounds were evaluated via a single high\u2010dose assay (10\u2005\u03bcM) against 60 cancer cell lines by the National Cancer Institute (USA) according to its screening protocol. Among them, compounds <jats:bold>2<\/jats:bold> and <jats:bold>10<\/jats:bold> exhibited the highest activity against the 60 cancer cell lines panel in the one\u2010dose assay. Compounds <jats:bold>2<\/jats:bold> and <jats:bold>10<\/jats:bold> showed inhibitory activity within the GI<jats:sub>50<\/jats:sub> parameter and in five dose analyses. However, their cytostatic activity was only observed against some cancer cell lines, and cytotoxic concentration was outside the maximum used, i.\u2009e., &gt;100\u2005\u03bcM. The COMPARE analysis showed that the average graphs of the tested compounds have a moderate positive correlation with compounds with the L\u2010cysteine analog and vinblastine (GI<jats:sub>50<\/jats:sub>) as well as paclitaxel (TGI), which target microtubules. Therefore, disruption of microtubule formation may be one of the mechanisms of the anticancer activity of the tested compounds, especially since among tubulin inhibitors with antitumor activity, compounds with an oxazole motif are widely represented. Therefore, <jats:italic>N<\/jats:italic>\u2010(4\u2010cyano\u20101,3\u2010oxazol\u20105\u2010yl)sulfonamides may be promising for further functionalization to obtain more active compounds.<\/jats:p>","DOI":"10.1002\/cmdc.202300527","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T11:50:18Z","timestamp":1705665018000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Synthesis, characterization of novel N\u2010(4\u2010cyano\u20101,3\u2010oxazol\u20105\u2010yl)sulfonamide derivatives and in\u2005vitro screening their activity against NCI\u201060\u2009cancer cell lines"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3943-5063","authenticated-orcid":false,"given":"Oleksandr","family":"Severin","sequence":"first","affiliation":[{"name":"Department of Chemistry of bioactive nitrogen-containing heterocyclic bases V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine  1, Academician Kukhar str 02094 Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7089-1393","authenticated-orcid":false,"given":"Stepan","family":"Pilyo","sequence":"additional","affiliation":[{"name":"Department of Chemistry of bioactive nitrogen-containing heterocyclic bases V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine  1, Academician Kukhar str 02094 Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1517-4807","authenticated-orcid":false,"given":"Maryna","family":"Kachaeva","sequence":"additional","affiliation":[{"name":"Department of Chemistry of bioactive nitrogen-containing heterocyclic bases V.P. 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