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The rational design of new inhibitors of GCS has been hampered by the lack of either the crystal structure of the enzyme or an in\u2010silico model of the active site which could provide important information regarding the interactions of potential inhibitors with the target, but, despite this, interesting results have been obtained and are herein reviewed.<\/jats:p>","DOI":"10.1002\/cmdc.202300641","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T11:14:19Z","timestamp":1707390859000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gaucher Disease: A Glance from a Medicinal Chemistry Perspective"],"prefix":"10.1002","volume":"19","author":[{"given":"Filippo","family":"Prencipe","sequence":"first","affiliation":[{"name":"Department of Chemical and Pharmaceutical Sciences University of Trieste  Via Licio Giorgieri 1 34127 Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Barzan","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Sciences University of Trieste  Via Licio Giorgieri 1 34127 Trieste Italy"},{"name":"Molecular Genetics Institute CNR Via Abbiategrasso 207  27100 Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Savian","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Sciences University of Trieste  Via Licio Giorgieri 1 34127 Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampiero","family":"Spalluto","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Sciences University of Trieste  Via Licio Giorgieri 1 34127 Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-5035","authenticated-orcid":false,"given":"Emanuele","family":"Carosati","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Sciences University of Trieste  Via Licio Giorgieri 1 34127 Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"De Amici","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences University of Milano Via Luigi Mangiagalli 25  20133 Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Mosconi","sequence":"additional","affiliation":[{"name":"Fidia Farmaceutici Via Ponte della Fabbrica 3\/A  35021 Abano Terme Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Gianferrara","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Sciences University of Trieste  Via Licio Giorgieri 1 34127 Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Federico","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Sciences University of Trieste  Via Licio Giorgieri 1 34127 Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-1560","authenticated-orcid":false,"given":"Tatiana","family":"Da Ros","sequence":"additional","affiliation":[{"name":"Department of Chemical and Pharmaceutical Sciences University of Trieste  Via Licio Giorgieri 1 34127 Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,8]]},"reference":[{"key":"e_1_2_11_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-019-0508-0"},{"key":"e_1_2_11_2_1","unstructured":"Epidemiological Data http:\/\/www.orphadata.org\/cgi-bin\/epidemio.html."},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","unstructured":"T. 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