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While Cu(II) complexes, featuring diverse ancillary ligands, dominate the field, exploration of silver and gold species remains limited. These complexes exhibit significant cytotoxicity against various cancer cell lines with a commendable selectivity for non\u2010tumorigenic cells. DNA interactions, employing intercalation and groove binding, are pivotal and finely tuned through terpyridine ligand functionalization. In addition, copper complexes showcase nuclease activity, triggering apoptosis through ROS generation. Despite silver\u2018s high affinity for nitrogen donor atoms, its exploration is relatively sparse, with indications of acting as intercalating agents causing DNA hydrolytic cleavage. Gold(III) compounds, overshadowing gold(I) due to stability concerns, not only intercalate but also induce apoptosis and disrupt the mitochondrial membrane. Further investigations are needed to fully understand the mechanism of action of these compounds, highlighting the necessity of exploring additional biological targets for these promising metallodrugs.<\/jats:p>","DOI":"10.1002\/cmdc.202300645","type":"journal-article","created":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T04:04:16Z","timestamp":1707365056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The Therapeutic Potential in Cancer of Terpyridine\u2010Based Metal Complexes Featuring Group\u200511 Elements"],"prefix":"10.1002","volume":"19","author":[{"given":"Mar\u00eda","family":"Gil\u2010Moles","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica Instituto de S\u00edntesis Qu\u00edmica y Cat\u00e1lisis Homog\u00e9nea (ISQCH) CSIC-Universidad de Zaragoza  Pedro Cerbuna 12 50009 Zaragoza Spain"},{"name":"Departamento de Qu\u00edmica Centro de Investigaci\u00f3n 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