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We assessed the anti\u2010cancer effect of a mixed ligand Ni(II) complex on human breast and lung cancer cell lines in this investigation. Mononuclear mixed ligand octahedral Ni(II) complex [<jats:bold>Ni<jats:sup>II<\/jats:sup>L<\/jats:bold>(<jats:bold>NO<jats:sub>3<\/jats:sub><\/jats:bold>)(<jats:bold>MeOH<\/jats:bold>)] complex\u2005(<jats:bold>1<\/jats:bold>), with tri\u2010dentate phenol\u2010based ligand 2,4\u2010dichloro\u20106\u2010((4\u2010methylpiperazin\u20101\u2010yl) methyl) phenol (<jats:bold>HL<\/jats:bold>) along with methanol and nitrate as ancillary ligand was prepared. Piperazine moiety of the ligand exists as boat conformation in this complex as revealed from single crystal X\u2010ray study. UV\u2013visible spectrum of complex\u2005(1) exhibits three distinct d\u2010d bands due to spin\u2010allowed 3\u2005A2\u2005g\u21923T1\u2005g (P), 3\u2005A2\u2005g\u21923T1\u2005g(F) and 3\u2005A2\u2005g\u21923T2\u2005g(F) transitions as expected in an octahedral d<jats:sup>8<\/jats:sup> system. Our study revealed that Complex\u2005(1) induces apoptotic cell death in mouse and human cancer cells such as mcf\u20107, A549 and MDA\u2010MB\u2010231 through transactivation of p53 and its pro\u2010apoptotic downstream targets in a dose dependent manner. Furthermore, complex\u2005(1) was able to slow the migratory rate of MDA\u2010MB\u2010231 cells\u2032 <jats:italic>in\u2005vitro<\/jats:italic> as well as epithelia \u2010mesenchymal transition (EMT), the key step for metastatic transition and malignancy. Over all our results suggest complex\u2005(1) as a potential agent in anti\u2010tumor treatment regimen showing both cytotoxic and anti\u2010metastatic activity against malignant neoplasia.<\/jats:p>","DOI":"10.1002\/cmdc.202300728","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T04:49:36Z","timestamp":1715921376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Novel Octahedral Nickel\u2005(II) Complex with Flexible Piperazinyl Moiety Exhibits Potent Cytotoxic Effect Along with Anti\u2010Migratory and Anti\u2010Metastatic Effect on Human Cancer Cells"],"prefix":"10.1002","volume":"19","author":[{"given":"Bikramaditya","family":"Mandal","sequence":"first","affiliation":[{"name":"Department of Chemical Sciences Indian Institute of Science Education and Research (IISER) Mohali, Sector\u201381, Knowledge City  Manauli -140306 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anik","family":"Pramanik","sequence":"additional","affiliation":[{"name":"Immunobiology and translational medicine laboratory Department of Zoology Sidho Kanho Birsha University  Purulia 723104 West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debanjan","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Immunobiology and translational medicine laboratory Department of Zoology Sidho Kanho Birsha University  Purulia 723104 West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwesha","family":"Haldar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sidho-Kanho-Birsha University  Purulia 723104 West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dona","family":"Das","sequence":"additional","affiliation":[{"name":"Immunobiology and translational medicine laboratory Department of Zoology Sidho Kanho Birsha University  Purulia 723104 West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Chemistry Kazi Nazrul University, Asansol  Paschim Bardhaman -713340 West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debdas","family":"Mandal","sequence":"additional","affiliation":[{"name":"Department of Chemistry Sidho-Kanho-Birsha University  Purulia 723104 West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3235-4220","authenticated-orcid":false,"given":"Sankar","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Immunobiology and translational medicine laboratory Department of Zoology Sidho Kanho Birsha University  Purulia 723104 West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers3033279"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2013.00028"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr980421n"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr980420v"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00623551"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1691"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2003.08.014"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1595\/003214001X4526269"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr068207j"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3DT51641E"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/b715077f"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ic901791f"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-004-0531-6"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2006.02.013"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr020010d"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","unstructured":"M. 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