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Here, we study the inhalation of a redox nano medicine namely citrate functionalized Mn<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> (C\u2212Mn<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>) duly encapsulated in droplet evaporated aerosols for the balancing of oxidative stress generated by the exposure of Chromium (VI) ion, a potential lung carcinogenic agent. Our optical spectroscopic in\u2010vitro experiments demonstrates the efficacy of redox balancing of the encapsulated nanoparticles (NP) for the maintenance of a homeostatic condition. The formation of Cr\u2010NP complex as an excretion of the heavy metal is also demonstrated through optical spectroscopic and high resolution transmission optical microscopy (HRTEM). Our studies confirm the oxidative stress mitigation activity of the Cr\u2010NP complex. A detailed immunological assay followed by histopathological studies and assessment of mitochondrial parameters in pre\u2010clinical mice model with chromium (Cr) induced lung inflammation establishes the mechanism of drug action to be redox\u2010buffering. Thus, localised delivery of C\u2212Mn<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> NPs in the respiratory tract via aerosols can act as an effective nanotherapeutic agent against oxidative stress induced lung inflammation.<\/jats:p>","DOI":"10.1002\/cmdc.202400037","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T01:13:59Z","timestamp":1709946839000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Targeted Redox Balancing through Pulmonary Nanomedicine Delivery Reverses Oxidative Stress Induced Lung Inflammation"],"prefix":"10.1002","volume":"19","author":[{"given":"Ria","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Biochemistry University of Calcutta  35, Ballygunge Circular Rd Kolkata 700019 India"},{"name":"Department of Chemical and Biological Sciences S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake  Kolkata 700 106 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monojit","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Zoology Vidyasagar University, Rangamati  Midnapore 721102 India"},{"name":"Department of Zoology Uluberia College University of Calcutta, Uluberia  Howrah 711315 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susmita","family":"Mondal","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biological Sciences S. N. Bose National Centre for Basic Sciences, Block JD, Sector III, Salt Lake  Kolkata 700 106 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrita","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Physics Jadavpur University  188, Raja S.C. 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