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The metal complexes were characterized by elemental analyses, molar conductivity, <jats:sup>1<\/jats:sup>H and <jats:sup>13<\/jats:sup>C{<jats:sup>1<\/jats:sup>H} nuclear magnetic resonance, UV\u2010Vis, infrared and EPR spectroscopies. The antifungal activity of these metal complexes was evaluated against the main sporotrichosis agents: <jats:italic>Sporothrix brasiliensis, Sporothrix schenkii<\/jats:italic>, and <jats:italic>Sporothrix globosa<\/jats:italic>. All three new compounds inhibited the growth of <jats:italic>S. brasiliensis<\/jats:italic> and <jats:italic>S. schenckii<\/jats:italic> at lower concentrations than the free azole, with complex <jats:bold>2<\/jats:bold> able to kill all species at 4\u2005\u03bcM and induce more pronounced alterations in fungal cells. Complexes <jats:bold>2<\/jats:bold> and <jats:bold>3<\/jats:bold> exhibited higher selectivity and no mutagenic effect at the concentration that inhibited fungal growth and affected fungal cells. The strategy of coordinating itraconazole (ITZ) to copper was successful, since the corresponding metal complexes were more effective than the parent drug. Particularly, the promising antifungal activity of the Cu\u2010ITZ complexes makes them potential candidates for the development of an alternative drug to treat mycoses.<\/jats:p>","DOI":"10.1002\/cmdc.202400054","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T15:28:27Z","timestamp":1714145307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010<i>Sporothrix<\/i> Activity of Novel Copper\u2010Itraconazole Complexes"],"prefix":"10.1002","volume":"19","author":[{"given":"Jos\u00e9 Aleixo","family":"de Azevedo\u2010Fran\u00e7a","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Juiz de Fora  Juiz de Fora Minas Gerais Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luana Pereira","family":"Borba\u2010Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Celular de Fungos Centro de Pesquisa em Medicina de Precis\u00e3o Instituto de Biof\u00edsica Carlos Chagas Filho Universidade Federal do Rio de Janeiro  Rio de Janeiro Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Let\u00edcia Mota Candal","family":"de Matos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inova\u00e7\u00e3o Farmac\u00eautica e Tecnol\u00f3gica Departamento de Gen\u00e9tica e Biologia Molecular Universidade Federal do Estado do Rio de Janeiro  Rio de Janeiro Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara Verena Dias","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Mutag\u00eanese Ambiental Departamento de Biof\u00edsica e Biometria Universidade do Estado do Rio de Janeiro  Rio de Janeiro RJ Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Fernando","family":"Araujo\u2010Lima","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Inova\u00e7\u00e3o Farmac\u00eautica e Tecnol\u00f3gica Departamento de Gen\u00e9tica e Biologia Molecular Universidade Federal do Estado do Rio de Janeiro  Rio de Janeiro Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel","family":"Felzenszwalb","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Mutag\u00eanese Ambiental Departamento de Biof\u00edsica e Biometria Universidade do Estado do Rio de Janeiro  Rio de Janeiro RJ Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanderley","family":"de Souza","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Ultraestrutura Celular Hertha Meyer Centro de Pesquisa em Medicina de Precis\u00e3o Instituto de Biof\u00edsica Carlos Chagas Filho Universidade Federal do Rio de Janeiro  Rio de Janeiro Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Adolfo","family":"Horn","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Santa Catarina  Florian\u00f3polis SC Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo S.","family":"Neves","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Santa Catarina  Florian\u00f3polis SC Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Rozental","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Celular de Fungos Centro de Pesquisa em Medicina de Precis\u00e3o Instituto de Biof\u00edsica Carlos Chagas Filho Universidade Federal do Rio de Janeiro  Rio de Janeiro Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8772-0312","authenticated-orcid":false,"given":"Maribel","family":"Navarro","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Juiz de Fora  Juiz de Fora Minas Gerais Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"World Health Organization (WHO). 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