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Phloroglucinol (PG) is a natural product contained in extracts of plant, algae and microbe and has been reported to have antioxidant and anti\u2010inflammatory properties. In this study, we synthesized PG derivatives to enhance antioxidant and anti\u2010inflammatory activity. Among PG derivatives, <jats:bold>6\u2009a<\/jats:bold> suppressed pro\u2010oxidative and inflammatory molecule nitric oxide (NO) production more effectively than PG. Moreover, <jats:bold>6\u2009a<\/jats:bold> dose\u2010dependently reduced the expression of proinflammatory cytokines such as IL\u20106, IL\u20101\u03b2, TNF\u2010\u03b1, and NO producing enzyme iNOS in lipopolysaccharide (LPS)\u2010stimulated BV\u20102 microglial cells. Additionally, we confirmed that <jats:bold>6\u2009a<\/jats:bold> alleviated cognitive impairment and glial activation in mouse model of LPS\u2010induced neuroinflammation. These findings suggest that novel PG derivative, <jats:bold>6\u2009a<\/jats:bold>, is a potential treatment for neurodegenerative diseases.<\/jats:p>","DOI":"10.1002\/cmdc.202400056","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T22:23:46Z","timestamp":1715898226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Phloroglucinol Derivatives Exert Anti\u2010Inflammatory Effects and Attenuate Cognitive Impairment in LPS\u2010Induced Mouse Model"],"prefix":"10.1002","volume":"19","author":[{"given":"Jushin","family":"Kim","sequence":"first","affiliation":[{"name":"Center for Brain Disorders Brain Science Institute Korea Institute of Science &amp; Technology (KIST)  02792 Seoul Republic of Korea"},{"name":"Department of Biotechnology Yonsei University  03722 Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Won Choi","sequence":"additional","affiliation":[{"name":"Center for Brain Disorders Brain Science Institute Korea Institute of Science &amp; 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