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The compounds reported here were generally inactive against both off\u2010target isoforms (<jats:italic>K<jats:sub>I<\/jats:sub><\/jats:italic>&gt;100\u2005\u03bcM), while all of them moderately inhibited both target isoforms hCA IX and XII in the submicromolar to micromolar ranges in which <jats:italic>K<jats:sub>I<\/jats:sub><\/jats:italic> values spanned from 0.57 to 8.4\u2005\u03bcM against hCA IX and from 0.34 to 9.7 against hCA XII. Due to the notable selectivity of the title compounds toward isoforms hCA IX and XII, they can be considered as useful scaffolds for further chemical optimization to develop new highly selective antitumor agents.<\/jats:p>","DOI":"10.1002\/cmdc.202400197","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T09:59:21Z","timestamp":1719395961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Synthesis and Carbonic Anhydrase I, II, IX, and XII Inhibition Studies with a Series of Cyclic Sulfonyl Guanidines"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1647-4262","authenticated-orcid":false,"given":"Morteza","family":"Abdoli","sequence":"first","affiliation":[{"name":"Institute of Chemistry and Chemical Technology Faculty of Natural Sciences and Technology Riga Technical University  P. 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